Evidence map›Paper›PMID 33312088›Full record

ArticleCurrent immunology reviews2019

HIV and SIV in Body Fluids: From Breast Milk to the Genitourinary Tract.

Kattayoun Kordy, Nicole H Tobin, Grace M Aldrovandi

Abstract read
In one paragraph

Article in Current immunology reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kattayoun KordyDepartment of Pediatrics, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
Nicole H TobinDepartment of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Grace M AldrovandiDepartment of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.

Funding

LC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2M
Maturation, Infectibility, and Trauma(MIT) Contributes to HIV Susceptibility in AdolescentsR01AI128796 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALDROVANDI, GRACE M, ANTON, PETER A · 2017 to 2020
$2.4M
NIAID NIH HHS R01 AI128796NIAID NIH HHS UM1 AI106716
6 · The paper itself

Abstract

HIV-1 is present in many secretions including oral, intestinal, genital, and breast milk. However, most people exposed to HIV-1 within these mucosal compartments do not become infected despite often frequent and repetitive exposure over prolonged periods of time. In this review, we discuss what is known about the levels of cell-free HIV RNA, cell-associated HIV DNA and cell-associated HIV RNA in external secretions. Levels of virus are usually lower than contemporaneously obtained blood, increased in settings of inflammation and infection, and decreased in response to antiretroviral therapy. Additionally, each mucosal compartment has unique innate and adaptive immune responses that affect the composition and presence of HIV-1 within each external secretion. We discuss the current state of knowledge about the types and amounts of virus present in the various excretions, touch on innate and adaptive immune responses as they affect viral levels, and highlight important areas for further study.

Indexed as

breast milkcell-associated DNAcell-associated RNACell-associated viruscell-free viruscervicovaginal fluidsgenital tractHIVHIV RNAinfected leucocytesmucosal transmissionnon-human primatesrectumsalivasemenSIVvaginavertical disease transmission

Identifiers

PMID33312088
PMCPMC7730163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.