Evidence map›Paper›PMID 33311950›Full record

ArticleWorld journal of gastroenterology2020

Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study.

Chong-Fei Huang, Jun-Jun Huang, Ning-Ning Mi, Yan-Yan Lin, Qiang-Sheng He, Ya-Wen Lu, Ping Yue, Bing Bai, Jin-Duo Zhang, Chao Zhang and 6 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07091526 (Whether Controlling Serum Uric Acid), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07091526 recruitingnot on this mapstarted 2025, after this paper: background citation

Whether Controlling Serum Uric Acid (SUA) Can Benefit Postoperative Survival in Patients With Pancreatic Cancer

TypeobservationalSponsorHepatopancreatobiliary Surgery Institute of Gansu ProvinceRan2025 to 2026Enrolled168ConditionsSerum Uric AcidArmsserum uric acid test
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Chong-Fei HuangThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Jun-Jun HuangScientific Research and Planning Department, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
Ning-Ning MiThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Yan-Yan LinSpecial Minimally Invasive Surgery Department, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
Qiang-Sheng HeClinical Research Center and Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China.
Ya-Wen LuThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Ping YueThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Bing BaiSpecial Minimally Invasive Surgery Department, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
Jin-Duo ZhangSpecial Minimally Invasive Surgery Department, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
Chao ZhangThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Teng CaiThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Wen-Kang FuThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Long GaoThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Xun LiGansu Province Institute of Hepatopancreatobiliary, Lanzhou 730000, Gansu Province, China.
Jin-Qiu YuanClinical Research Center and Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China.
Wen-Bo MengThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Lanzhou University · CN

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

backgroundUric acid is the end product of purine metabolism. Previous studies have found that serum uric acid (SUA) levels are associated with the total cancer risk. However, due to the dual effect of uric acid on cancer, the relationship between the SUA levels and most specific-site cancer remains unclear.

aimTo investigate the associations between the SUA levels and incidence of hepatobiliary-pancreatic cancer.

methodsIn this prospective cohort study, 444462 participants free of cancer from the UK Biobank were included. The SUA levels were measured at baseline, and the incidence of hepatobiliary-pancreatic cancer was determined by contacting the cancer registry. The hazard ratios (HRs) and 95% confidence intervals (CIs) between the SUA levels and hepatobiliary-pancreatic cancer were investigated using multiple adjusted Cox regression models adjusted for potential confounders.

resultsIn total, 920 participants developed liver, gallbladder, biliary tract or pancreatic cancer during a median of 6.6 yrs of follow-up. We found that the HR of pancreatic cancer in the highest SUA group was 1.77 (95%CI: 1.29-2.42) compared with that in the lowest group. After stratifying by gender, we further found that SUA was associated with an increased risk of pancreatic cancer only among the females (highest quartile

conclusionSUA is likely to have gender-specific effects on hepatobiliary-pancreatic cancer. High SUA levels are a risk factor for pancreatic cancer in females and gallbladder cancer in males. A U-shaped association with the liver cancer risk was identified.

Indexed as

Pancreatic NeoplasmsUric AcidCohort StudiesFemaleHumansMaleProspective StudiesRisk FactorsUric AcidBiliary tract neoplasmsCohort studiesGallbladder neoplasmsLiver neoplasmsPancreatic neoplasmsUric acid

Identifiers

PMID33311950
PMCPMC7701939
OpenAlexW3106727989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.