Evidence map›Paper›PMID 33311920›Full record

ArticleAnnals of pediatric cardiology

Birth prevalence and late diagnosis of critical congenital heart disease: A population-based study from a middle-income country.

Mohd Nizam Mat Bah, Mohd Hanafi Sapian, Emieliyuza Yusnita Alias

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Article in Annals of pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Mohd Nizam Mat BahDepartment of Pediatrics, Ministry of Health, Hospital Sultanah Aminah, Johor Bahru, Malaysia.
Mohd Hanafi SapianDepartment of Pediatrics, Ministry of Health, Hospital Sultanah Aminah, Johor Bahru, Malaysia.
Emieliyuza Yusnita AliasDepartment of Pediatrics, Ministry of Health, Hospital Sultanah Aminah, Johor Bahru, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThere are limited data regarding critical congenital heart disease (CCHD) from middle-income countries (MIC). This study aims to determine the birth prevalence, rate of late diagnosis, and influence of timing of diagnosis on the outcome of CCHD. SETTING AND

designRetrospective observational cohort study in the State of Johor, Malaysia. SUBJECTS AND

methodsAll infants born between January 2006 and December 2015 with a diagnosis of CCHD, defined as infants with duct-dependent lesions or cyanotic heart disease who may die without early intervention. The late diagnosis was defined as a diagnosis of CCHD after 3 days of age.

resultsCongenital heart disease was diagnosed in 3557 of 531,904 live-born infants and were critical in 668 (18.7%). Of 668, 347 (52%) had duct-dependent pulmonary circulation. The birth prevalence of CCHD was 1.26 (95% confidence interval: 1.16-1.35) per 1000 live births, with no significant increase over time. The median age of diagnosis was 4 days (Q1 1, Q3 26), with 61 (9.1%) detected prenatally, and 342 (51.2%) detected late. The highest rate of late diagnosis was observed in coarctation of the aorta with a rate of 74%. Trend analysis shows a statistically significant reduction of late diagnosis and a significant increase in prenatal detection. However, Cox regression analysis shows the timing of diagnosis does not affect the outcome of CCHD.

conclusionsDue to limited resources in the MIC, the late diagnosis of CCHD is high but does not affect the outcome. Nevertheless, the timing of diagnosis has improved over time.

Indexed as

Birth prevalencecritical congenital heart diseaselate diagnosismiddle-income country

Identifiers

PMID33311920
PMCPMC7727899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.