ArticleJournal of clinical and experimental hepatology
Serum Leptin Serves as an Inflammatory Activity Marker and Predicts Steroid Response in Autoimmune Hepatitis.
Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- CCL22 and Leptin associated with steroid resistance in childhood idiopathic nephrotic syndrome.Frontiers in pediatrics · 2023Article
- Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis.The American journal of pathology · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
BACKGROUND AND
aimAdipocytokines, especially leptin is involved in a wide spectrum of proinflammatory functions, in various tissues. This study was carried out to assess the role of serum leptin in autoimmune hepatitis.
methodsSerum leptin was analyzed in treatment naïve autoimmune hepatitis (AIH, n = 48) patients and compared with the primary biliary cholangitis (PBC, n = 16), chronic hepatitis C (CHC, n = 16) and healthy controls (n = 15). Serum leptin correlation was assessed on liver function tests, disease activity, T regulatory cells (Tregs), and Th17 cells in the liver biopsies and on steroid treatment response in AIH.
resultsSerum leptin was higher in AIH than in PBC, CHC, and HC {AIH: 335 (106.2-580), PBC: 126 (52-381.2), CH: 67 (3.7-133.5) and HC: 66 (40-157.5) ng/ml;
conclusionSerum leptin is indicative of higher AIH activity and a reduced number of Tregs cells in liver biopsy tissue. Leptin negative cases have more chances of steroid responsiveness and could help in the selection of AIH cases for appropriate therapy.
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