Evidence map›Paper›PMID 33311847›Full record

ArticleJournal of leukocyte biology2020

Characterization and regulation of osteoclast precursors following chronic

Yanfang Zhao, Zhaofei Li, Lingkai Su, Andre Ballesteros-Tato, Jannet Katz, Suzanne M Michalek, Xu Feng, Ping Zhang

Open access · greenAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

  1. [Research Advances on the Role of the Oral Microbiota in Age-Related Homeostatic Dysregulation and Systemic Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yanfang ZhaoDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Zhaofei LiDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Lingkai SuDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Andre Ballesteros-TatoDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Jannet KatzDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Suzanne M MichalekDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Xu FengDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Ping ZhangDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
University of Alabama at Birmingham · US

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
ROLE OF OSTEOCLAST PRECURSORS IN PERIODONTAL BONE LOSSR01DE026465 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, PING · 2017 to 2021
$2.1M
Dental Academic Research Training Program (DART)R90DE023056 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$913k
NIAID NIH HHS P30 AI027767NIAMS NIH HHS P30 AR048311NIDCR NIH HHS R01 DE026465NIDCR NIH HHS R90 DE023056NIDCR NIH HHS T90 DE022736
6 · The paper itself

Abstract

Bone destruction in inflammatory osteolytic diseases including periodontitis is related to excessive activity of osteoclasts (OC), which originate from precursor cells of the myeloid lineage, termed osteoclast precursors (OCP). In contrast to ample knowledge that we currently have on mature OC, little is known about OCP and their regulation during bacterial infection. Therefore, this study aimed to identify and characterize OCP following chronic infection with a periodontal bacteria

Indexed as

AnimalsBacteroidaceae InfectionsCell DifferentiationChronic DiseaseDisease Models, AnimalInterleukin-6MiceMice, KnockoutOsteoclastsOsteolysisPorphyromonas gingivalisStem CellsInterleukin-6interleukin-6, mouseosteoclastogenesisosteoclast precursorsosteoclastsPorphyromonas gingivalis

Identifiers

PMID33311847
PMCPMC7725479
OpenAlexW3061774679

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.