ArticleScientific reports2020
Liver lymphatic drainage patterns follow segmental anatomy in a murine model.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The tumor distance to the main hepatic vessels is a predictor of recurrence-free survival and overall survival in hepatocellular cancer.Langenbeck's archives of surgery · 2025Article
- VEGF-C propagates 'onward' colorectal cancer metastasis from liver to lung.British journal of cancer · 2025Article
- Lymphatic System Development and Function.Current cardiology reports · 2024Review
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- Prediction of regional lymph node metastasis in intrahepatic cholangiocarcinoma: it's not all about size.Abdominal radiology (New York) · 2023Article
- Fetal liver development and implications for liver disease pathogenesis.Nature reviews. Gastroenterology & hepatology · 2023Review
- Intratumoral dendritic cell-CD4Nature medicine · 2023Article
- Article
- Longitudinal Changes in MR Elastography-based Biomarkers in Obese Patients Treated with Bariatric Surgery.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Article
- Hepatic lymphatic vascular system in health and disease.Journal of hepatology · 2022Review
- Liver lymphatic drainage patterns follow segmental anatomy.The British journal of surgery · 2022Article
- Volumetric imaging reveals VEGF-C-dependent formation of hepatic lymph vessels in mice.Frontiers in cell and developmental biology · 2022Article
- Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer.The American journal of pathology · 2021Review
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The liver's cellular functions are sustained by a hierarchical, segmentally-organized vascular system. Additionally, liver lymphatic vessels are thought to drain to perihepatic lymph nodes. Surprisingly, while recent findings highlight the importance of organ-specific lymphatics, the functional anatomy of liver lymphatics has not been mapped out. In literature, no segmental or preferential lymphatic drainage patterns are known to exist. We employ a novel murine model of liver lymphangiography and in vivo microscopy to delineate the lymphatic drainage patterns of individual liver lobes. Our data from blue dye liver lymphangiography show preferential lymphatic drainage patterns: Right lobe mainly to hepatoduodenal ligament lymph node 1 (LN1); left lobe to hepatoduodenal ligament LN1 + LN2 concurrently; median lobe showed a more variable LN1/LN2 drainage pattern with increased (sometimes exclusive) mediastinal thoracic lymph node involvement, indicating that part of the liver can drain directly to the mediastinum. Upon ferritin lymphangiography, we observed no functional communication between the lobar lymphatics. Altogether, these results show the existence of preferential lymphatic drainage patterns in the murine liver. Moreover, this drainage can occur directly to mediastinal lymph nodes and there is no interlobar lymphatic flow. Collectively, these data provide the first direct evidence that liver lymphatic drainage patterns follow segmental anatomy.
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