SynthesisCommunications biology2020
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Human Crystallin Variation and Cataract.Investigative ophthalmology & visual science · 2026Review
- Autophagy in ocular diseases: from mechanisms to therapeutic potential.Frontiers in cell and developmental biology · 2026Review
- Whole Exome Sequencing Study Uncovers Novel Candidate Genes and Protein-Coding Variants for Cataract.Investigative ophthalmology & visual science · 2025Article
- Oxidative Stress in Genetic Cataract Formation.Antioxidants (Basel, Switzerland) · 2024Review
- Anti-Cataract Effect of the Traditional Aqueous Extract of Yerba Mate (Life (Basel, Switzerland) · 2024Article
- Through theGenes · 2024Review
- Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults.Human genomics · 2024Article
- A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.Cells · 2024Article
- Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract.Frontiers in ophthalmology · 2024Article
- Charged multivesicular body protein 4b forms complexes with gap junction proteins during lens fiber cell differentiation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Review
- Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Review
- Sonic Hedgehog Intron Variant Associated With an Unusual Pediatric Cortical Cataract.Investigative ophthalmology & visual science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
55 authors at 18 institutions in 10 countries.
Ekaterina Yonova-DoingDepartment of Twin Research and Genetic Epidemiology, The School of Life Course Sciences, King's College London, London, SE1 7EH, UK.
Wanting ZhaoSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Robert P IgoEpidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID 0000-0002-0024-1993
Chaolong WangComputational and Systems Biology, Genome Institute of Singapore, 138672, Singapore, Singapore.ORCID 0000-0003-3945-1012
Periasamy SundaresanDepartment of Genetics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, 625020, India.
Kristine E LeeDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA.
Gyungah R JunDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0002-3230-8697
Alexessander Couto AlvesDepartment of Twin Research and Genetic Epidemiology, The School of Life Course Sciences, King's College London, London, SE1 7EH, UK.
Xiaoran ChaiSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Anita S Y ChanSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.ORCID 0000-0001-8602-9450
Mei Chin LeeSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Allan FongSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Ava G TanCentre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, 2145, Australia.
Chiea Chuen KhorSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.ORCID 0000-0002-1128-4729
Emily Y ChewNational Eye Institute, National Institutes of Health, Bethesda, MD, 20814, USA.ORCID 0000-0003-0999-9802
Pirro G HysiDepartment of Twin Research and Genetic Epidemiology, The School of Life Course Sciences, King's College London, London, SE1 7EH, UK.ORCID 0000-0001-5752-2510
Qiao FanSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Jacqueline ChuaSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Jaeyoon ChungHistology, Department of Pathology, Singapore General Hospital, 169856, Singapore, Singapore.ORCID 0000-0002-6431-9454
Jiemin LiaoSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Johanna M ColijnDepartment of Epidemiology, Erasmus Medical Centre, 3015 GD, Rotterdam, The Netherlands.
Kathryn P BurdonMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia.ORCID 0000-0001-8217-1249
Lars G FritscheCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-2110-1690
Maria K SwiftDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA.
Maryam H HilmyDepartment of Anatomical Pathology and Cytology, Singapore General Hospital, 169608, Singapore, Singapore.
Miao Ling CheeSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Milly TedjaDepartment of Epidemiology, Erasmus Medical Centre, 3015 GD, Rotterdam, The Netherlands.
Pieter W M BonnemaijerDepartment of Epidemiology, Erasmus Medical Centre, 3015 GD, Rotterdam, The Netherlands.ORCID 0000-0001-5154-6765
Preeti GuptaSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Queenie S TanInstitute of Molecular and Cell Biology, 138673, Singapore, Singapore.
Zheng LiDivision of Human Genetics, Genome Institute of Singapore, 138672, Singapore, Singapore.ORCID 0000-0002-7060-2213
Eranga N VithanaSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Ravilla D RavindranAravind Eye Hospital, Madurai, Tamil Nadu, 625020, India.
Soon-Phaik CheeSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Yuan ShiSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Wenting LiuDivision of Human Genetics, Genome Institute of Singapore, 138672, Singapore, Singapore.
Xinyi SuSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.ORCID 0000-0002-1480-6713
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore, 117549, Singapore, Singapore.ORCID 0000-0002-1233-7642
Yang ShenComputational and Systems Biology, Genome Institute of Singapore, 138672, Singapore, Singapore.
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, WC29+WV, Beijing, China.
Hengtong LiSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Yih-Chung ThamSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.ORCID 0000-0002-6752-797X
Yik Ying TeoSaw Swee Hock School of Public Health, National University of Singapore, 117549, Singapore, Singapore.
Tin AungSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Kerrin S SmallDepartment of Twin Research and Genetic Epidemiology, The School of Life Course Sciences, King's College London, London, SE1 7EH, UK.ORCID 0000-0003-4566-0005
Paul MitchellCentre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, 2145, Australia.
Jost B JonasBeijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, WC29+WV, Beijing, China.ORCID 0000-0003-2972-5227
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore.
Astrid E FletcherDepartment of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Seegartenklinik Heidelberg, 69115, Heidelberg, Germany.
Caroline C W KlaverDepartment of Epidemiology, Erasmus Medical Centre, 3015 GD, Rotterdam, The Netherlands.ORCID 0000-0002-2355-5258
Barbara E K KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA.
Jie Jin WangCentre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, 2145, Australia.
Sudha K IyengarEpidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, 44106, USA.
Christopher J HammondDepartment of Twin Research and Genetic Epidemiology, The School of Life Course Sciences, King's College London, London, SE1 7EH, UK. chris.hammond@kcl.ac.uk.ORCID 0000-0002-3227-2620
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Center, 168751, Singapore, Singapore. chingyu.cheng@duke-nus.edu.sg.ORCID 0000-0003-0655-885X
Singapore National Eye Center · SGNational University of Singapore · SGSingapore General Hospital · SGKing's College London · GBErasmus MC · NLGenome Institute of Singapore · SGThe University of Sydney · AUBeijing Tongren Hospital · CNCase Western Reserve University · USAravind Eye Hospital · INBoston University · USHeidelberg University · DEHuazhong University of Science and Technology · CNInstitute of Molecular and Cell Biology · SGNational Institutes of Health · USNorwegian University of Science and Technology · NORadboud University Nijmegen · NLUniversity of Tasmania · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable (h
Indexed as
Genetic Predisposition to DiseaseGenetic VariationAllelesCataractGenetic Association StudiesGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideSOXB1 Transcription FactorsSOX2 protein, humanSOXB1 Transcription Factors
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.