Evidence map›Paper›PMID 33311473›Full record

ArticleNature communications2020

SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8

Lucie Loyal, Sarah Warth, Karsten Jürchott, Felix Mölder, Christos Nikolaou, Nina Babel, Mikalai Nienen, Sibel Durlanik, Regina Stark, Beate Kruse and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 70 citations in OpenAlex.

  1. T Cell Thoughts.Immunological reviews · 2026
    Review
  2. Article
  3. CD4Frontiers in immunology · 2026
    Article
  4. DNA methylation profiling of human CD4Immunology and cell biology · 2026
    Article
  5. Nanomaterials Trigger Functional Anti-Tumoral Responses in Primary Human Immune Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Article
  8. CD8Science advances · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. SLAMF7 (CD319) on activated CD8Cell death and differentiation · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. From PsO to PsA: the role of TFrontiers in medicine · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Lucie LoyalSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany.
Sarah WarthRegenerative Immunology and Aging, BIH Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany.
Karsten JürchottRegenerative Immunology and Aging, BIH Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany.
Felix MölderGenome Informatics, Institute of Human Genetics, Universität Duisburg-Essen, 45147, Essen, Germany.ORCID 0000-0002-3976-9701
Christos NikolaouRegenerative Immunology and Aging, BIH Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany.ORCID 0000-0001-6018-3564
Nina BabelMedical Clinic I, Marien Hospital Herne, Ruhr Universität Bochum, 44625, Herne, Germany.
Mikalai NienenInstitute for Medical Immunology, Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany.
Sibel DurlanikRegenerative Immunology and Aging, BIH Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany.
Regina StarkAdaptive Immunity Lab, Department of Hematopoiesis, Sanquin Blood Supply Foundation, 1066, Amsterdam, The Netherlands.ORCID 0000-0001-7693-799X
Beate KruseSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany.
Marco FrentschRegenerative Immunology and Aging, BIH Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany.
Robert SabatPsoriasis Research and Treatment Center, Dermatology/Medical Immunology, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Kerstin WolkPsoriasis Research and Treatment Center, Dermatology/Medical Immunology, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.ORCID 0000-0002-7689-4130
Andreas ThielSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin, 13353, Berlin, Germany. andreas.thiel@charite.de.ORCID 0000-0002-5515-4002
Charité - Universitätsmedizin Berlin · DEBerlin-Brandenburger Centrum für Regenerative Therapien · DEHumboldt-Universität zu Berlin · DESanquin · NLUniversitätsklinik Marien Hospital Herne · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevailing 'division of labor' concept in cellular immunity is that CD8

Indexed as

AnimalsCD40 LigandCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationChemokinesCytokinesCytotoxicity, ImmunologicGene ExpressionHumansImmunity, CellularMiceMice, Inbred C57BLReceptors, Interleukin-6Signaling Lymphocytic Activation Molecule FamilySkinCD40 LigandChemokinesCytokinesReceptors, Interleukin-6Signaling Lymphocytic Activation Molecule FamilySLAMF7 protein, human

Identifiers

PMID33311473
PMCPMC7733515
OpenAlexW3111613708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.