ArticleScience advances2020
A fully biodegradable and self-electrified device for neuroregenerative medicine.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed.
- Artificial intelligence and peripheral neuropathies: Strategies for the development, application, and repair of regenerative biomaterials.Neural regeneration research · 2026Article
- Biointegrated Battery-Based Electroceuticals.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Strategies of Designing High-Efficiency Electrolyte Additives for Aqueous Magnesium Batteries: A Review.Nano-micro letters · 2026Review
- Ultra-flexible optoelectronic stimulator converts tissue-attenuated weak light into electrical signals for cardiac remodeling.Nature communications · 2026Article
- Safe, high-performance, moisture-activated batteries for powering next-generation Internet-of-Things devices.Science advances · 2026Article
- Hierarchical microtopology and phase-specific delivery functionally restore ultralong nerve continuity across species.Science advances · 2026Article
- Engineering technology of implantable galvanic cells for silencing the bone-neural axis in gouty arthritis therapy.Nature communications · 2026Article
- Peripheral nerve repair: innovations and future directions.Journal of translational medicine · 2026Review
- Rochelle salt-based biodegradable piezoelectric devices for nerve regeneration and intestinal motility monitoring.Nature communications · 2026Article
- A self-wrapping, bioresorbable neural interface for wireless multimodal therapy of localized peripheral nerve injury.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Electroactive biomaterials modulating ion channels in nervous system regeneration.Regenerative biomaterials · 2026Review
- Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications.Advanced healthcare materials · 2026Review
- Piezoelectric-hydrogen synergy in electrospun oriented fibrous scaffold enables multimodal repair of long-distance peripheral nerve defect.Regenerative biomaterials · 2026Article
- Galvanic-Cell-Based Self-Powered Bioelectronic Devices.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Thermo-responsive shape memory biomaterials with structural and physical adaptivity for scarless personalized nerve repair.Materials today. Bio · 2025Article
- Highly tough and conformal silk-based adhesive patches for sutureless repair of gastrointestinal and peripheral nerve defects.Bioactive materials · 2025Article
- A micro-patterned transient UV photodetector enabled by solvent-free microfabrication.Microsystems & nanoengineering · 2025Article
- Applications of advances in therapeutic electrical stimulation techniques and technologies in precision peripheral nerve repair: a narrative review.Advanced technology in neuroscience · 2025Article
- Advances in Symbiotic Bioabsorbable Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues.Nature reviews bioengineering · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve regeneration remains one of the greatest challenges in regenerative medicine. Deprivation of sensory and/or motor functions often occurs with severe injuries even treated by the most advanced microsurgical intervention. Although electrical stimulation represents an essential nonpharmacological therapy that proved to be beneficial for nerve regeneration, the postoperative delivery at surgical sites remains daunting. Here, a fully biodegradable, self-electrified, and miniaturized device composed of dissolvable galvanic cells on a biodegradable scaffold is achieved, which can offer both structural guidance and electrical cues for peripheral nerve regeneration. The electroactive device can provide sustained electrical stimuli beyond intraoperative window, which can promote calcium activity, repopulation of Schwann cells, and neurotrophic factors. Successful motor functional recovery is accomplished with the electroactive device in behaving rodent models. The presented materials options and device schemes provide important insights into self-powered electronic medicine that can be critical for various types of tissue regeneration and functional restoration.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.