Evidence map›Paper›PMID 33310678›Full record

ArticleBiomaterials2021

Cellular remodeling of fibrotic conduit as vascular graft.

Xuefeng Qiu, Benjamin Li-Ping Lee, Sze Yue Wong, Xili Ding, Kang Xu, Wen Zhao, Dong Wang, Ryan Sochol, Nianguo Dong, Song Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  11. ECM roles and biomechanics in cardiac tissue decellularization.American journal of physiology. Heart and circulatory physiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Xuefeng QiuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Department of Bioengineering, University of California, Berkeley, CA, 94720, USA; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Benjamin Li-Ping LeeDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Sze Yue WongDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Xili DingDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Kang XuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Department of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Wen ZhaoDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA; Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, China.
Dong WangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Department of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Ryan SocholDepartment of Mechanical Engineering, University of Maryland, College Park, MD, 20742, USA.
Nianguo DongDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: 1986xh0694@hust.edu.cn.
Song LiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Department of Bioengineering, University of California, Berkeley, CA, 94720, USA; Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: songli@ucla.edu.
University of California, Los Angeles · USUnion Hospital · CNUniversity of California, Berkeley · USNorthwestern Polytechnical University · CNUniversity of Maryland, College Park · US

Funding

Tissue Engineered Nanofibrous Vascular GraftR01HL083900 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI LI, SONG · 2006 to 2010
$2.0M
Multipotent stem cells for tissue regenerationR01EB012240 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI LI, SONG · 2010 to 2013
$1.9M
In Situ Regeneration of Blood VesselR01HL121450 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2015 to 2018
$1.8M
NHLBI NIH HHS R01 HL083900NHLBI NIH HHS R01 HL121450NIBIB NIH HHS R01 EB012240
6 · The paper itself

Abstract

The replacement of small-diameter arteries remains an unmet clinical need. Here we investigated the cellular remodeling of fibrotic conduits as vascular grafts. The formation of fibrotic conduit around subcutaneously implanted mandrels involved not only fibroblasts but also the trans-differentiation of inflammatory cells such as macrophages into fibroblastic cells, as shown by genetic lineage tracing. When fibrotic conduits were implanted as vascular grafts, the patency was low, and many fibrotic cells were found in neointima. Decellularization and anti-thrombogenic coating of fibrotic conduits produced highly patent autografts that remodeled into neoarteries, offering an effective approach to obtain autografts for clinical therapy. While autografts recruited mostly anti-inflammatory macrophages for constructive remodeling, allogenic DFCs had more T cells and pro-inflammatory macrophages and lower patency. Endothelial progenitors and endothelial migration were observed during endothelialization. Cell infiltration into DFCs was more efficient than decellularized arteries, and infiltrated cells remodeled the matrix and differentiated into smooth muscle cells (SMCs). This work provides insight into the remodeling of fibrotic conduits, autologous DFCs and allogenic DFCs, and will have broad impact on using fibrotic matrix for regenerative engineering.

Indexed as

BioprosthesisBlood Vessel Prosthesis ImplantationArteriesBlood Vessel ProsthesisExtracellular MatrixHumansVascular PatencyVascular RemodelingDecellularizationFibrosisInflammatory cellsVascular graft

Identifiers

PMID33310678
PMCPMC7856276
OpenAlexW3108330989

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.