Evidence map›Paper›PMID 33310623›Full record

ReviewCurrent opinion in chemical biology2021

Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases.

Lan Na, Riyao Li, Xi Chen

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  3. Journal of microbiology and biotechnology · 2026
    Article
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  6. Review
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  9. Pan-genome analysis ofFrontiers in microbiology · 2024
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  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lan NaDepartment of Chemistry, University of California Davis, Davis, CA, USA.
Riyao LiDepartment of Chemistry, University of California Davis, Davis, CA, USA.
Xi ChenDepartment of Chemistry, University of California Davis, Davis, CA, USA. Electronic address: xiichen@ucdavis.edu.
University of California, Davis · US

Funding

Chemoenzymatic synthesis of bacterial polysaccharidesU01GM125288 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KIESSLING, LAURA L, LI, LEI · 2017 to 2020
$3.1M
Facile chemoenzymatic synthesis and purification of glycolipidsU01GM120419 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI · 2016 to 2019
$2.8M
Supplement: Exploring the biology of O-acetyl sialic acids using stable synthetic mimicsR01AI130684 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI, VARKI, AJIT P · 2017 to 2020
$2.3M
NIAID NIH HHS R01 AI130684NIGMS NIH HHS U01 GM120419NIGMS NIH HHS U01 GM125288
6 · The paper itself

Abstract

Sugar nucleotide-dependent glycosyltransferases (GTs) are key enzymes that catalyze the formation of glycosidic bonds in nature. They have been increasingly applied in the synthesis of complex carbohydrates and glycoconjugates with or without in situ generation of sugar nucleotides. Human GTs are becoming more accessible and new bacterial GTs have been identified and characterized. An increasing number of crystal structures elucidated for GTs from mammalian and bacterial sources facilitate structure-based design of mutants as improved catalysts for synthesis. Automated platforms have also been developed for chemoenzymatic synthesis of carbohydrates. Recent progress in applying sugar nucleotide-dependent GTs in enzymatic and chemoenzymatic synthesis of mammalian glycans and glycoconjugates, bacterial surface glycans, and glycosylated natural products from bacteria and plants are reviewed.

Indexed as

AnimalsCarbohydratesGlycosyltransferasesHumansNucleotidesCarbohydratesGlycosyltransferasesNucleotidesBiocatalystCarbohydrateChemoenzymatic synthesisEnzymatic synthesisGlycosyltransferaseSugar nucleotide

Identifiers

PMID33310623
PMCPMC8106622
OpenAlexW3110695681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.