SynthesisJournal of affective disorders2021
Prevalence of mental health problems during the COVID-19 pandemic: A systematic review and meta-analysis.
Synthesis in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 624 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
624 citing papers in PubMed, 12 syntheses or guidelines pooled it, 1,172 citations in OpenAlex.
- Effectiveness of Telehealth Care Interventions for Women's Mental Health During and After the COVID-19 Pandemic: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- The effect of virtual reality technology on the intervention of mental health problems among healthcare workers: a systematic review.Frontiers in public health · 2026Pooled it
- Was the COVID-19 Pandemic a Triggering Factor for PTSD in Adults? Results From A Systematic Review.Actas espanolas de psiquiatria · 2025Pooled it
- Prevalence of anxiety, depression, and post-traumatic stress disorder among paramedic students: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2025Pooled it
- An umbrella review of the prevalence of depression during the COVID-19 pandemic: Call to action for post-COVID-19 at the global level.BMC public health · 2024Pooled it
- Suicide rates before and during the COVID-19 pandemic: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2024Pooled it
- Estimation of the prevalence of anxiety during the COVID-19 pandemic: A meta-analysis of meta-analyses.BMC public health · 2024Pooled it
- Impacts of COVID-19 on mental health of students in Ethiopia: systematic review and meta-analysis.BMC psychology · 2024Pooled it
- Pooled it
- Risk factors of developing psychological problems among frontline healthcare professionals working in the COVID-19 pandemic era: a meta-analysis.BMC public health · 2023Pooled it
- Cost Effectiveness of Pharmacological and Non-pharmacological Treatments for Depression in Low- and Middle-Income Countries: A Systematic Literature Review.PharmacoEconomics · 2023Pooled it
- The prevalence of probable mental health disorders among hospital healthcare workers during COVID-19: A systematic review and meta-analysis.Journal of affective disorders · 2023Pooled it
- A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain.Journal of pain research · 2025Trial
- Trial
- Supplementation with whey peptide rich in β-lactolin improves trait anxiety and subjective stress in healthy adults: a randomized, double-blind, placebo-controlled study.Scientific reports · 2024Trial
- Evaluation and Future Challenges in a Self-Guided Web-Based Intervention With and Without Chat Support for Depression and Anxiety Symptoms During the COVID-19 Pandemic: Randomized Controlled Trial.JMIR formative research · 2024Trial
- Developing a brief assessment of social risks for the Veterans Health Administration Survey of Healthcare Experiences of Patients.Health services research · 2023Trial
- Effects and Mechanisms of a Web- and Mobile-Based Acceptance and Commitment Therapy Intervention for Anxiety and Depression Symptoms in Nurses: Fully Decentralized Randomized Controlled Trial.Journal of medical Internet research · 2023Trial
- Impacts of Perceived Discrimination During the COVID-19 Pandemic on Depression Among Older Chinese Immigrants in Aotearoa New Zealand.Journal of aging and health · 2026Article
- Burden of disease in anxiety disorders: trends, projections and relationship to human resources for health.Discover mental health · 2026Article
564 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe global COVID-19 pandemic has generated major mental and psychological health problems worldwide. We conducted a meta-analysis to assess the prevalence of depression, anxiety, distress, and insomnia during the COVID-19 pandemic.
methodsWe searched online biomedical databases (PubMed, Embase, Web of Science, Ovid, CNKI, and Wanfang Data) and preprint databases (SSRN, bioRxiv, and MedRxiv) for observational studies from January 1, 2020 to March 16, 2020 investigating the prevalence of mental health problems during the COVID-19 pandemic.
resultsWe retrieved 821 citations from the biomedical databases and 53 citations from the preprint databases: 66 studies with 221,970 participants were included in our meta-analysis. The overall pooled prevalence of depression, anxiety, distress, and insomnia was 31.4%, 31.9%, 41.1% and 37.9%, respectively. Noninfectious chronic disease patients, quarantined persons, and COVID-19 patients had a higher risk of depression (Q=26.73, p<0.01) and anxiety (Q=21.86, p<0.01) than other populations. The general population and non-medical staff had a lower risk of distress than other populations (Q=461.21, p< 0.01). Physicians, nurses, and non-medical staff showed a higher prevalence of insomnia (Q=196.64, p<0.01) than other populations. LIMITATIONS: All included studies were from the early phase of the global pandemic. Additional meta-analyses are needed to obtain more data in all phases of the pandemic.
conclusionsThe COVID-19 pandemic increases the mental health problems of the global population, particularly health care workers, noninfectious chronic disease patients, COVID-19 patients, and quarantined persons. Interventions for mental health are urgently needed for preventing mental health problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.