Evidence map›Paper›PMID 33310301›Full record

ArticleCell calcium2021

T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function.

Lukun Yang, Elena N Dedkova, Paul D Allen, M Saleet Jafri, Alla F Fomina

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Frontiers in immunology · 2026
    Article
  2. Article
  3. Current Practices in Pharmacogenomics.Pediatric clinics of North America · 2023
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Lukun YangDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, 95616, USA; Department of Anesthesiology, the 5th Affiliated Hospital of SUN YAT-SEN University, Zhuhai, 519000, China. Electronic address: yanglk@mail.sysu.edu.cn.
Elena N DedkovaDepartment of Molecular Biosciences, University of California, Davis, Davis, CA, 95616, USA. Electronic address: ededkova@ucdavis.edu.
Paul D AllenDepartment of Molecular Biosciences, University of California, Davis, Davis, CA, 95616, USA; MH Unit, St. James's University Hospital, University of Leeds, Leeds, LS9 7TF, United Kingdom. Electronic address: p.d.allen@leeds.ac.uk.
M Saleet JafriSchool of Systems Biology, George Mason University, Fairfax, VA, 22030, USA. Electronic address: sjafri@gmu.edu.
Alla F FominaDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, 95616, USA. Electronic address: affomina@ucdavis.edu.
University of California, Davis · USGeorge Mason University · USSun Yat-sen University · CNUniversity of Leeds · GB

Funding

Fumarate drugs rescue cardiac dysfunction in mouse models of Friedreich's ataxiaR01HL155907 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DEDKOVA, ELENA N. · 2021 to 2024
$1.8M
Mechanisms controlling Ca2+ dyshomeostasis in MH susceptible miceR01AR068897 · NIAMS · UNIVERSITY OF LEEDS · PI ALLEN, PAUL D · 2016 to 2020
$1.2M
NHLBI NIH HHS R01 HL155907NIAMS NIH HHS R01 AR068897
6 · The paper itself

Abstract

Gain-of-function RyR1-p.R163C mutation in ryanodine receptors type 1 (RyR1) deregulates Ca

Indexed as

Calcium SignalingAnimalsCalciumCell ProliferationGenotypeIntracellular SpaceLymphocyte ActivationMachine LearningMalignant HyperthermiaMembrane Potential, MitochondrialMiceMitochondriaMutant ProteinsThapsigarginT-LymphocytesCalciumMutant ProteinsThapsigarginDantrolene sodiumIntracellular Ca(2+)Mitochondrial potentialRyanodine receptorRYR1-p.R163C knock-in miceT lymphocytes

Identifiers

PMID33310301
PMCPMC7840221
OpenAlexW3108293323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.