ArticleNeuroscience2021
Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling.
Article in Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Functional Clusters for Shape, Texture, and Motion Encoding in Macaque V2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Selective weakening of population-coupled synaptic activity in vivo in a mouse model of amyloid-beta pathology.Nature communications · 2026Article
- Unbiased Segmentation and Multifeature Classification of Cortical Neuronal Activity Reveals Complex Dynamics Under Anesthesia.Neuroscience bulletin · 2026Article
- Effects of Repeated Early-life Anesthesia Exposure on Visual System Development in Mice.Anesthesiology · 2026Article
- Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings.Microsystems & nanoengineering · 2026Article
- Functional clusters for shape, texture, and motion encoding in macaque V2.bioRxiv : the preprint server for biology · 2025Article
- Cortical state contributions to neuronal response variability in the early visual cortex: A system identification approach.PLoS computational biology · 2025Article
- Brain activity during intraoperative general anesthesia using resting-state functional magnetic resonance imaging ~ Feasibility study ~.Journal of anesthesia · 2025Article
- Repetitive training enhances the pattern recognition capability of cultured neural networks.PLoS computational biology · 2025Article
- Anesthesia alters complexity of spontaneous and stimulus-related neuronal firing patterns in rat visual cortex.Neuroscience · 2025Article
- Enhancing anesthetic techniques for improving whisker stimulation response in the barrel cortex.PloS one · 2025Article
- A high-density 1,024-channel probe for brain-wide recordings in non-human primates.Nature neuroscience · 2024Article
- Label-free photoacoustic computed tomography of visually evoked responses in the primary visual cortex and four subcortical retinorecipient nuclei of anesthetized mice.Neurophotonics · 2024Article
- Article
- Anesthetized animal experiments for neuroscience research.Frontiers in neural circuits · 2024Review
- Group ICA of wide-field calcium imaging data reveals the retrosplenial cortex as a major contributor to cortical activity during anesthesia.Frontiers in cellular neuroscience · 2024Article
- Microstimulation reveals anesthetic state-dependent effective connectivity of neurons in cerebral cortex.Frontiers in neuroscience · 2024Article
- Electric Field Effects on Brain Activity: Implications for Epilepsy and Burst Suppression.Cells · 2023Article
- Translational Organic Neural Interface Devices at Single Neuron Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons.Neuron · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cortical neurons display diverse firing patterns and synchronization properties. How anesthesia alters the firing response of different neuron groups relevant for sensory information processing is unclear. Here we investigated the graded effect of anesthesia on spontaneous and visual flash-induced spike activity of different neuron groups classified based on their spike waveform, firing rate, and population coupling (the extent neurons conform to population spikes). Single-unit activity was measured from multichannel extracellular recordings in deep layers of primary visual cortex of freely moving rats in wakefulness and at three concentrations of desflurane. Anesthesia generally decreased firing rate and increased population coupling and burstiness of neurons. Population coupling and firing rate became more correlated and the pairwise correlation between neurons became more predictable by their population coupling in anesthesia. During wakefulness, visual stimulation increased firing rate; this effect was the largest and the most prolonged in neurons that exhibited high population coupling and high firing rate. During anesthesia, the early increase in firing rate (20-150 ms post-stimulus) of these neurons was suppressed, their spike timing was delayed and split into two peaks. The late response (200-400 ms post-stimulus) of all neurons was also suppressed. We conclude that anesthesia alters the visual response of primarily high-firing highly coupled neurons, which may interfere with visual sensory processing. The increased association of population coupling and firing rate during anesthesia suggests a decrease in sensory information content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.