ReviewNeuroscience and biobehavioral reviews2021
Time to put the mammillothalamic pathway into context.
Review in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- MRI measures of hypothalamic injury are associated with glucagon-like peptide-1 receptor agonist treatment response in people with hypothalamic obesity.Diabetes, obesity & metabolism · 2021Trial
- A dorsal subiculum-medial mammillary body pathway for spatial memory.Molecular psychiatry · 2025Article
- Impairments of spatial memory retrieval via medial mammillary body dysfunction in Alzheimer's disease model.Translational psychiatry · 2025Article
- Two distinct cell types of the medial mammillary body forming segregated subcircuits.Molecular psychiatry · 2025Article
- Smaller hippocampal tail volume is associated with plasma CCL11 levels in patients with major depressive disorder.Psychological medicine · 2025Article
- Early onset of hyperexcitability of medial mammillary body neurons in 5XFADJournal of neurophysiology · 2025Article
- Parvalbumin Neurons in the Basal Forebrain Projecting to the Mammillary Nucleus Ameliorate Age-Related Cognitive Decline.International journal of molecular sciences · 2025Article
- A reappraisal of the role of the mammillothalamic tract in memory deficits following stroke in the thalamus.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Physiological characteristics of neurons in the mammillary bodies align with topographical organization of subicular inputs.Cell reports · 2024Article
- A Case With Bilateral Hippocampal Infarction Resembling Transient Global Amnesia.Journal of medical cases · 2024Article
- FNDC5/irisin mediates the protective effects of Innovative theta-shaking exercise on mouse memory.Heliyon · 2024Article
- Electrophysiological Properties of the Medial Mammillary Bodies across the Sleep-Wake Cycle.eNeuro · 2024Article
- Modeling the contribution of theta-gamma coupling to sequential memory, imagination, and dreaming.Frontiers in neural circuits · 2024Article
- The Cortico-Limbo-Thalamo-Cortical Circuits: An Update to the Original Papez Circuit of the Human Limbic System.Brain topography · 2023Review
- Korsakoff's Syndrome and Alzheimer's Disease-Commonalities and Specificities of Volumetric Brain Alterations within Papez Circuit.Journal of clinical medicine · 2023Article
- A model of working memory for encoding multiple items and ordered sequences exploiting the theta-gamma code.Cognitive neurodynamics · 2023Article
- Enhancement of astrocytic gap junctions Connexin43 coupling can improve long-term isoflurane anesthesia-mediated brain network abnormalities and cognitive impairment.CNS neuroscience & therapeutics · 2022Article
- Characterization of Two MouseInternational journal of molecular sciences · 2022Article
- The anterior thalamic nuclei: core components of a tripartite episodic memory system.Nature reviews. Neuroscience · 2022Review
- Construction of complex memories via parallel distributed cortical-subcortical iterative integration.Trends in neurosciences · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The medial diencephalon, in particular the mammillary bodies and anterior thalamic nuclei, has long been linked to memory and amnesia. The mammillary bodies provide a dense input into the anterior thalamic nuclei, via the mammillothalamic tract. In both animal models, and in patients, lesions of the mammillary bodies, mammillothalamic tract and anterior thalamic nuclei all produce severe impairments in temporal and contextual memory, yet it is uncertain why these regions are critical. Mounting evidence from electrophysiological and neural imaging studies suggests that mammillothalamic projections exercise considerable distal influence over thalamo-cortical and hippocampo-cortical interactions. Here, we outline how damage to the mammillary body-anterior thalamic axis, in both patients and animal models, disrupts behavioural performance on tasks that relate to contextual ("where") and temporal ("when") processing. Focusing on the medial mammillary nuclei as a possible 'theta-generator' (through their interconnections with the ventral tegmental nucleus of Gudden) we discuss how the mammillary body-anterior thalamic pathway may contribute to the mechanisms via which the hippocampus and neocortex encode representations of experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.