Evidence map›Paper›PMID 33309840›Full record

ArticleNeurotoxicology2021

Exposure to bisphenol A differentially impacts neurodevelopment and behavior in Drosophila melanogaster from distinct genetic backgrounds.

U Nguyen, B Tinsley, Y Sen, J Stein, Y Palacios, A Ceballos, C Welch, K Nzenkue, A Penn, L Murphy and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Neurotoxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Biological and Behavioral Responses ofInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Decoding Nucleotide Repeat Expansion Diseases: Novel Insights fromInternational journal of molecular sciences · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

U NguyenDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
B TinsleyDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
Y SenDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
J SteinDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
Y PalaciosDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
A CeballosDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
C WelchDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
K NzenkueDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
A PennDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
L MurphyDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
K LeodonesDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
J CasiquinDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
I IvoryDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
K GhentaDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
K DanzigerDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
E WidmanDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
J NewmanDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
M TriplehornDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
Z HindiDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States.
K MulliganDepartment of Biological Sciences, California State University, Sacramento, 6000 J Street, Sacramento, CA, 95819, United States. Electronic address: kimberly.mulligan@csus.edu.
California State University, Sacramento · US

Funding

Establishing Drosophila melanogaster as a model for determining gene-environment interactions that confer risk of autism using bisphenols and the autism risk gene, fragile x mental retardation 1SC2GM132005 · NIGMS · CALIFORNIA STATE UNIVERSITY SACRAMENTO · PI MULLIGAN, KIMBERLY ANNE · 2019 to 2021
$426k
NIGMS NIH HHS SC2 GM132005
6 · The paper itself

Abstract

Bisphenol A (BPA) is a ubiquitous environmental chemical that has been linked to behavioral differences in children and shown to impact critical neurodevelopmental processes in animal models. Though data is emerging, we still have an incomplete picture of how BPA disrupts neurodevelopment; in particular, how its impacts may vary across different genetic backgrounds. Given the genetic tractability of Drosophila melanogaster, they present a valuable model to address this question. Fruit flies are increasingly being used for assessment of neurotoxicants because of their relatively simple brain structure and variety of measurable behaviors. Here we investigated the neurodevelopmental impacts of BPA across two genetic strains of Drosophila-w

Indexed as

AnimalsBenzhydryl CompoundsBisphenol A CompoundsCourtshipDisease Models, AnimalDrosophila melanogasterFemaleFragile X SyndromeGroomingLarvaLocomotionMaleNervous SystemPhenolsBenzhydryl Compoundsbisphenol ABisphenol A CompoundsPhenolsAxon guidanceBehaviorBisphenol ADrosophila melanogasterFragile X syndromeNeuroblasts

Identifiers

PMID33309840
PMCPMC8075300
OpenAlexW3112222634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.