Evidence map›Paper›PMID 33309638›Full record

ReviewMolecular and cellular endocrinology2021

The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system.

Carlos M Ferrario, Leanne Groban, Hao Wang, Che Ping Cheng, Jessica L VonCannon, Kendra N Wright, Xuming Sun, Sarfaraz Ahmad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular and cellular endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Review
  6. Role of Mast Cells and Their Mediators in Chronic Kidney Diseases.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Immunomodulation of Myocardial Fibrosis.JACC. Basic to translational science · 2023
    Review
  11. Internalization of Angiotensin-(1-12) in Adult Retinal Pigment Epithelial-19 Cells.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlos M FerrarioDepartment of Surgery and Physiology-Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA. Electronic address: cferrari@wakehealth.edu.
Leanne GrobanDepartment of Anesthesiology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Hao WangDepartment of Anesthesiology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Che Ping ChengDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA.
Jessica L VonCannonDepartment of Surgery and Physiology-Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Kendra N WrightDepartment of Surgery and Physiology-Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Xuming SunDepartment of Anesthesiology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Sarfaraz AhmadDepartment of Surgery and Physiology-Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA.

Funding

Vaso-Hormonal Mechanisms in HypertensionP01HL051952 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FERRARIO, CARLOS M · 1994 to 2019
$34.8M
Angiotensin (1-12) and Hypertension in the ElderlyR21AG070371 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FERRARIO, CARLOS M · 2021 to 2022
$426k
NHLBI NIH HHS P01 HL051952NIA NIH HHS R21 AG070371
6 · The paper itself

Abstract

The identification of an alternate extended form of angiotensin I composed of the first twelve amino acids at the N-terminal of angiotensinogen has generated new knowledge of the importance of noncanonical mechanisms for renin independent generation of angiotensins. The human sequence of the dodecapeptide angiotensin-(1-12) [N-Asp

Indexed as

Adrenal GlandsAngiotensin IAngiotensin IIAngiotensinogenAnimalsBiocatalysisBone MarrowBrainCardiovascular DiseasesChymasesGene ExpressionHumansIntestinesKidneyMyocardiumPeptide FragmentsAGT protein, humanangiotensin-(1-12), humanAngiotensin IAngiotensin IIAngiotensinogenChymasesCMA1 protein, humanPeptide FragmentsAngiotensin-(1–12)Angiotensin-converting enzymeAngiotensin IAngiotensin IIAngiotensinogenAngiotensin peptidesChymaseMetabolismReninRenin-angiotensin system

Identifiers

PMID33309638
PMCPMC8127338

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.