Evidence map›Paper›PMID 33309567›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022

A Novel Biomarker of Neuronal Glutamate Metabolism in Nonhuman Primates Using Localized

Corin O Miller, Liza T Gantert, Stephen F Previs, Ying Chen, Kenneth D Anderson, Justina M Thomas, Gerard Sanacora, Jason M Uslaner, Douglas L Rothman, Graeme F Mason

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Reproducibility of the Determination ofNMR in biomedicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Corin O MillerDepartment of Translational Imaging Biomarkers, Merck & Co., Kenilworth, New Jersey. Electronic address: corin_miller@merck.com.
Liza T GantertDepartment of Translational Imaging Biomarkers, Merck & Co., Kenilworth, New Jersey.
Stephen F PrevisDepartment of Chemistry, Merck & Co., Kenilworth, New Jersey.
Ying ChenDepartment of Chemistry, Merck & Co., Kenilworth, New Jersey.
Kenneth D AndersonDepartment of Pharmacology, Pharmacokinetics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey.
Justina M ThomasDepartment of Pharmacology, Pharmacokinetics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey.
Gerard SanacoraDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Jason M UslanerDepartment of Neuroscience, Merck & Co., Kenilworth, New Jersey.
Douglas L RothmanDepartment of Diagnostic Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut; Department of Biomedical Engineering Yale University School of Medicine, New Haven, Connecticut.
Graeme F MasonDepartment of Diagnostic Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Merck & Co., Inc., Rahway, NJ, USA (United States) · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETESR01DK020495 · NIDDK · YALE UNIVERSITY · PI ROTHMAN, DOUGLAS LYLE · 1986 to 2022
$6.6M
Brain Acetate and Ethanol Metabolism in Alcohol Dependence and AbuseR01AA021984 · NIAAA · YALE UNIVERSITY · PI MASON, GRAEME F. · 2013 to 2017
$2.7M
Comprehensive, Cross Platform-Validated 13C Flux Measures of Intra-and Inter-tissue MetabolismR01DK108283 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MASON, GRAEME F. · 2016 to 2019
$2.1M
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS R01 AA021984NIDDK NIH HHS R01 DK020495NIDDK NIH HHS R01 DK108283
6 · The paper itself

Abstract

backgroundThe development of treatments for cognitive deficits associated with central nervous system disorders is currently a significant medical need. Despite the great need for such therapeutics, a significant challenge in the drug development process is the paucity of robust biomarkers to assess target modulation and guide clinical decisions. We developed a novel, translatable biomarker of neuronal glutamate metabolism, the

methodsWe began with numerical simulations in an established model of brain glutamate metabolism, showing that the

resultsThe

conclusionsThis study demonstrates that the ratio of

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorGlutamic AcidAnimalsBenzethoniumBiomarkersChlorobenzenesHumansMacaca mulattaMagnetic Resonance SpectroscopyMalealpha7 Nicotinic Acetylcholine ReceptorBenzethoniumBiomarkersBNC375ChlorobenzenesGlutamic AcidBiomarkerGlutamateImagingMRSNicotinic acetylcholine receptorPositive allosteric modulator

Identifiers

PMID33309567
PMCPMC8005500
OpenAlexW3091445120

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.