Evidence map›Paper›PMID 33309483›Full record

ArticleVaccine2021

Effects of rotavirus NSP4 protein on the immune response and protection of the S

Cunbao Liu, Pengwei Huang, Dandan Zhao, Ming Xia, Weiming Zhong, Xi Jiang, Ming Tan

Open access · greenAbstract read
In one paragraph

Article in Vaccine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. EngineeringVaccines · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. The αTSR Domain ofInternational journal of nanomedicine · 2023
    Article
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Cunbao LiuInstitute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan Province, China.
Pengwei HuangDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Dandan ZhaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Ming XiaDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Weiming ZhongDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Xi JiangDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ming TanDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: Ming.Tan@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · USChinese Academy of Medical Sciences & Peking Union Medical College · CNSouthern Medical University · CN

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
Novel vaccine against NorovirusR01AI089634 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI JIANG, XI · 2010 to 2014
$4.7M
A Nanoparticle-Based Multivalent Rotavirus VaccineR56AI148426 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI TAN, MING · 2020 to 2020
$626k
NCATS NIH HHS UL1 TR001425NIAID NIH HHS R01 AI089634NIAID NIH HHS R56 AI148426NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

Rotavirus causes severe diarrhea and dehydration in young children. Even with the implementation of the current live vaccines, rotavirus infections still cause significant mortality and morbidity, indicating a need for new rotavirus vaccines with improved efficacy. To this end, we have developed an S

Indexed as

NanoparticlesRotavirusRotavirus InfectionsRotavirus VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralImmunityMiceViral Nonstructural ProteinsAntibodies, NeutralizingAntibodies, ViralRotavirus VaccinesViral Nonstructural ProteinsNon-replicating rotavirus vaccineNorovirusRotavirusRotavirus NSP4Rotavirus vaccineRotavirus VP8S(R69A)-VP8*/S(60)-VP8* nanoparticle

Identifiers

PMID33309483
PMCPMC7822095
OpenAlexW3112625395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.