ArticleBiological psychiatry2021
Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress.
Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Distinct depressive-like behavioural phenotypes in mice exhibit unique patterns of transcriptional perturbations across habenular cell subtypes.Molecular psychiatry · 2026Article
- Continuous OFT-Based Behavioral Phenotyping Reveals Neural Stem Cell-Associated Shifts in Depression-like Mice.Brain sciences · 2026Article
- Characterization of a novel female chronic social defeat stress (femCSDS) model utilizing persistently aggressive CD1 parous females.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Multidimensional behavioral profiles associated with resilience and susceptibility after inescapable stress.Scientific reports · 2024Article
- A comparison of machine learning methods for quantifying self-grooming behavior in mice.Frontiers in behavioral neuroscience · 2024Article
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
- Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress.Nature communications · 2023Article
- Steady electrocorticogram characteristics predict specific stress-induced behavioral phenotypes.Frontiers in neuroscience · 2023Article
- Epigenetic embedding of childhood adversity: mitochondrial metabolism and neurobiology of stress-related CNS diseases.Frontiers in molecular neuroscience · 2023Review
- Modern views of machine learning for precision psychiatry.Patterns (New York, N.Y.) · 2022Review
- Assessing negative affect in mice during abstinence from alcohol drinking: Limitations and future challenges.Alcohol (Fayetteville, N.Y.) · 2022Review
- A physiological profile approach to animal temperament: How to understand the functional significance of individual differences in behaviour.Proceedings. Biological sciences · 2022Review
- Chronic, but not sub-chronic, stress increases binge-like alcohol consumption in male and female c57BL6 mice.Frontiers in behavioral neuroscience · 2022Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe study of depression in humans depends on animal models that attempt to mimic specific features of the human syndrome. Most studies focus on one or a few behavioral domains, with time and practical considerations prohibiting a comprehensive evaluation. Although machine learning has enabled unbiased analysis of behavior in animals, this has not yet been applied to animal models of psychiatric disease.
methodsWe performed chronic social defeat stress (CSDS) in mice and evaluated behavior with PsychoGenics' SmartCube, a high-throughput unbiased automated phenotyping platform that collects >2000 behavioral features based on machine learning. We evaluated group differences at several times post-CSDS and after administration of the antidepressant medication imipramine.
resultsSmartCube analysis after CSDS successfully separated control and defeated-susceptible mice, and defeated-resilient mice more resembled control mice. We observed a potentiation of CSDS effects over time. Treatment of susceptible mice with imipramine induced a 40.2% recovery of the defeated-susceptible phenotype as assessed by SmartCube.
conclusionsHigh-throughput analysis can simultaneously evaluate multiple behavioral alterations in an animal model for the study of depression, which provides a more unbiased and holistic approach to evaluating group differences after CSDS and perhaps can be applied to other mouse models of psychiatric disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.