Evidence map›Paper›PMID 33308631›Full record

ArticleMaturitas2021

Association of adverse childhood experiences with menopausal symptoms: Results from the Data Registry on Experiences of Aging, Menopause and Sexuality (DREAMS).

Ekta Kapoor, Madison Okuno, Virginia M Miller, Liliana Gazzuola Rocca, Walter A Rocca, Juliana M Kling, Carol L Kuhle, Kristin C Mara, Felicity T Enders, Stephanie S Faubion

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maturitas, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Childhood adversity and gynecological conditions.Case reports in women's health · 2022
    Article
  11. Adverse Childhood Experiences and Subjective Cognitive Decline in the US.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ekta KapoorCenter for Women's Health, Mayo Clinic, 200 First St SW, Rochester, MN, USA; Division of General Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, USA; Division of Endocrinology, Diabetes, Metabolism, & Nutrition, Mayo Clinic, 200 First St SW, Rochester, MN, USA. Electronic address: Kapoor.ekta@mayo.edu.
Madison OkunoUniversity of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN, USA.
Virginia M MillerDepartments of Surgery and Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN, USA.
Liliana Gazzuola RoccaDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN, USA.
Walter A RoccaDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN, USA; Women's Health Research Center, Mayo Clinic, 200 First St SW, Rochester, MN, USA; Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN, USA.
Juliana M KlingDivision of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Carol L KuhleCenter for Women's Health, Mayo Clinic, 200 First St SW, Rochester, MN, USA; Division of General Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, USA.
Kristin C MaraDivision of Biomedical Statistics and Informatics, Mayo Clinic, 200 First St SW, Rochester, MN, USA.
Felicity T EndersDivision of Biomedical Statistics and Informatics, Mayo Clinic, 200 First St SW, Rochester, MN, USA.
Stephanie S FaubionCenter for Women's Health, Mayo Clinic, 200 First St SW, Rochester, MN, USA; Division of General Internal Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, USA.
Mayo Clinic · USMayo Clinic in Arizona · USUniversity of Minnesota Medical Center · US

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
NIA NIH HHS U54 AG044170
6 · The paper itself

Abstract

objectiveTo examine the association of adverse childhood experiences (ACEs) with overall menopausal symptom burden in midlife women. STUDY

designThis was a cross-sectional study of women between the ages of 40 and 65 years who were seen for specialty consultation in the Menopause and Women's Sexual Health Clinic, Mayo Clinic, Rochester, MN between May 1, 2015 and December 31, 2016.

main outcome measuresParticipants completed the ACE questionnaire to assess childhood abuse and neglect, the Menopause Rating Scale (MRS) to assess menopausal symptom burden, the Patient Health Questionnaire (PHQ-9) to assess depression, the Generalized Anxiety Disorder questionnaire (GAD-7) to assess anxiety, and provided information on current abuse (physical, sexual and verbal/emotional).

resultsWomen meeting inclusion criteria (N = 1670) had a median age of 53.7 years (interquartile range: 49.1, 58.0). Of these women, 977 (58.5 %) reported any ACE and 288 (17.2 %) reported ≥4 ACEs. As menopausal symptoms increased in severity from the first to fourth quartile, the odds ratio of ACE 1-3 (vs. 0) increased from 1 to 2.50 (trend p < 0.01), and the odds ratio of ACE ≥ 4 (vs. 0) increased from 1 to 9.61 (trend p < 0.01), a pattern that was consistent across all menopausal symptom domains. The association between severe menopausal symptoms and higher childhood adversity (ACE score 1-3 or ≥4 vs. ACE = 0) remained significant after adjusting for age, partner status, education, employment, depression, anxiety, and hormone therapy use (OR 1.84 and 4.51, p < 0.01).

conclusionIn this large cross-sectional study, there was a significant association between childhood adversity and self-reported menopausal symptoms that persisted even after adjustment for multiple confounders. These associations highlight the importance of screening women with bothersome menopausal symptoms for childhood adversity, and of offering appropriate management and counseling for the adverse experiences, when indicated.

Indexed as

Adverse Childhood ExperiencesAgingMenopauseAdultAgedAnxietyChildChild AbuseCross-Sectional StudiesDepressionFemaleHumansMiddle AgedSexualityAdverse childhood experiencesChild abuseHot flashesMenopausal symptomsVasomotor symptoms

Identifiers

PMID33308631
PMCPMC7880696
OpenAlexW3092928397

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.