Evidence map›Paper›PMID 33308411›Full record

Observational studyJournal of studies on alcohol and drugs2020

Effects of Polygenic Risk and Perceived Friends' Drinking and Disruptive Behavior on Development of Alcohol Use Across Adolescence.

Michelle J Zaso, Stephen A Maisto, Stephen J Glatt, Jonathan L Hess, Aesoon Park

Open access · greenAbstract readObservational Study
PubMed Full text at PMC
In one paragraph

Observational study in Journal of studies on alcohol and drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michelle J ZasoDepartment of Psychology, Syracuse University, Syracuse, New York.
Stephen A MaistoDepartment of Psychology, Syracuse University, Syracuse, New York.
Stephen J GlattThe State University of New York (SUNY) Upstate Medical University, Syracuse, New York.
Jonathan L HessThe State University of New York (SUNY) Upstate Medical University, Syracuse, New York.
Aesoon ParkDepartment of Psychology, Syracuse University, Syracuse, New York.
SUNY Upstate Medical University · USSyracuse University · USUniversity at Buffalo, State University of New York · US

Funding

RESEARCH TRAINING ON ALCOHOL ETIOLOGY AND TREATMENTT32AA007583 · NIAAA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Gregory G Homish, KENNETH E LEONARD · 2000 to 2026
$8.5M
Pathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental StudyR01AA018333 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M, KENDLER, KENNETH SEEDMAN · 2010 to 2014
$2.8M
Racial Differences in Developmental and Daily Sleep-Alcohol Associations in YouthR01AA027677 · NIAAA · SYRACUSE UNIVERSITY · PI PARK, AESOON · 2019 to 2023
$1.8M
Person-environment interplay in alcohol use and consequences among Black youthR15AA022496 · NIAAA · SYRACUSE UNIVERSITY · PI PARK, AESOON · 2014 to 2014
$395k
Interplay between Peer-based Processes and Alcohol Metabolism Genes on Trajectories of Alcohol Use across AdolescenceF31AA025833 · NIAAA · SYRACUSE UNIVERSITY · PI ZASO, MICHELLE JOSEPHINE · 2017 to 2018
$49k
Medical Research Council 092731Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009NIAAA NIH HHS F31 AA025833NIAAA NIH HHS R01 AA018333NIAAA NIH HHS R01 AA027677NIAAA NIH HHS R15 AA022496NIAAA NIH HHS T32 AA007583Wellcome TrustWellcome Trust 102215/2/13/2
6 · The paper itself

Abstract

objectiveDevelopmental theory posits interacting individual and contextual factors that contribute to alcohol use across adolescence. Despite the well-documented salience of peer environmental influences on adolescent drinking, it is not known whether peer environments moderate polygenic risks for trajectories of alcohol use. The current theoretically based investigation aimed to test developmental gene-environment interaction (G×E) effects across adolescence.

methodLatent growth curve models tested interactive associations of polygenic risk scores and adolescents' perceived friend drinking and disruptive behavior with adolescents' initial level of alcohol use frequency at age 16 years old and change in alcohol frequency from ages 16 to 20. The sample comprised 8,941 White adolescents (49% female) from Great Britain within the Avon Longitudinal Study of Parents and Children (ALSPAC).

resultsGreater polygenic risk was associated with more frequent initial drinking as well as escalations in drinking frequency over the subsequent 5 years in latent growth curve models. Contrary to study hypotheses, no significant G×E effects were identified after controlling for confounding main and interaction effects.

conclusionsAdolescents at heightened genetic risk may accelerate their alcohol use across adolescence, although not significantly more so in the presence of these alcohol-promoting peer environments. Future well-powered, theoretically driven replication efforts are needed to examine generalizability of these findings across diverse samples.

Indexed as

Peer GroupAdolescentAlcohol DrinkingFemaleFriendsGene-Environment InteractionHumansLongitudinal StudiesMaleMultifactorial InheritanceProblem BehaviorProspective StudiesRisk FactorsUnderage DrinkingUnited KingdomYoung Adult

Identifiers

PMID33308411
PMCPMC7754848
OpenAlexW3112157294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.