Evidence map›Paper›PMID 33308312›Full record

ArticleClinical sarcoma research2020

Locally recurrent extraskeletal myxoid chondrosarcoma of the shoulder: a case of complete neoadjuvant radiotherapy response.

Luca Improta, Sergio Valeri, Rossana Alloni, Chiara Pagnoni, Francesco Mallozzi Santa Maria, Beniamino Brunetti, Carlo Greco, Irene Aprile, Mirella Maselli, Bruno Vincenzi and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Clinical sarcoma research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Luca ImprotaCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy.
Sergio ValeriCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy. s.valeri@unicampus.it.
Rossana AlloniCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy.
Chiara PagnoniCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy.
Francesco Mallozzi Santa MariaCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy.
Beniamino BrunettiCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy.
Carlo GrecoCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy.
Irene AprileIRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, Italy.
Mirella MaselliCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy.
Bruno VincenziCampus Bio-Medico University of Rome, Via Alvaro del Portillo, 200, 00128, Roma, RM, Italy.
Alessandro GronchiFondazione IRCCS Istituto Nazionale Dei Tumori, Via Venezian, 1, 20133, Milan, MI, Italy.
Università Campus Bio-Medico · ITDon Carlo Gnocchi Foundation · ITFondazione IRCCS Istituto Nazionale dei Tumori · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue tumor that typically affects the lower limbs of men between the ages of 50 and 60. EMC of the shoulder is rare with a high risk of local recurrence and distant metastasis. A planned surgical excision in sarcoma referral centers (SRCs) is mandatory to obtain the best outcome. The role of chemotherapy (CHT) and Radiotherapy (RT) on soft tissue chondrosarcoma is still controversial. CASE PRESENTATION: A 47-year-old man presented to our referral center with a history of EMC in the right shoulder excised with microscopic positive surgical margins in a non-referral center. Staging imaging exams did not reveal distant metastasis or residual disease, but during follow-up a local recurrence was detected. After a multidisciplinary discussion, preoperative radiotherapy was administered with a total dose of 50 Gy, and then the patient underwent wide surgical excision. Histological examination was negative for viable tumor cells. No relapse occurred in a 24-months post-operative follow up.

conclusionsThe case here described suggests the importance of patient's management in SRCs. A planned combined treatments with both surgery and RT seems to be the best choice to improve local control. RT seems to be promising within this specific histotype. Further studies are needed to confirm if the observed efficacy of combined treatments reflects in a consistent survival benefit for EMC patients.

Indexed as

Extraskeletal myxoid chondrosarcoma (EMC)Preoperative radiotherapySarcoma referral centers (SRCs)Soft tissue sarcoma (STS)Wide surgical margins

Identifiers

PMID33308312
PMCPMC7731621
OpenAlexW3112243411

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.