ArticleBMC chemistry2020
Extracts of medicinal plants with natural deep eutectic solvents: enhanced antimicrobial activity and low genotoxicity.
Article in BMC chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Enhanced extraction and functional properties of 3-deoxyanthocyanidins from red sorghum leaf sheaths via ultrasound-assisted extraction with natural deep eutectic solvent.Ultrasonics sonochemistry · 2026Article
- Recent Developments in Sustainable Solubilization.ChemSusChem · 2026Article
- Antimicrobial and Antioxidant Effects of Aqueous, Methanolic, and a Deep Eutectic Solvent-Based Extracts ofScientifica · 2026Article
- Safety of NADES Extract ofMolecules (Basel, Switzerland) · 2025Article
- Eco friendly deep eutectic solvent based extraction of Raphanus sativus leaf bioactives with mechanistic and antibacterial evaluation.Scientific reports · 2025Article
- Comparative Ultrasonic Bath and Probe Extraction of Piperine fromBiomolecules · 2025Article
- Green extraction of poplar type propolis: ultrasonic extraction parameters and optimization via response surface methodology.BMC chemistry · 2025Article
- Microwave-assisted extraction of bioactive compounds from Urtica dioica using solvent-based process optimization and characterization.Scientific reports · 2025Article
- Extraction of Bioactive Compounds fromPlants (Basel, Switzerland) · 2025Article
- Novel Buccal Xanthan Gum-Hyaluronic Acid Eutectogels with Dual Anti-Inflammatory and Antimicrobial Properties.Gels (Basel, Switzerland) · 2025Article
- Natural Deep Eutectic Solvents as Green Alternatives for Extracting Bioactive Compounds fromAntioxidants (Basel, Switzerland) · 2025Article
- Phytochemical and Pharmacological Properties of a Traditional Herb, Strobilanthes Cusia (Nees) Kuntze.Molecular biotechnology · 2024Article
- Exploring the Biosafety Potential ofCells · 2024Article
- Investigation of antifungal and antibacterial potential of green extracts of propolis.Scientific reports · 2024Article
- Article
- From Nature to Innovation: The Uncharted Potential of Natural Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2023Review
- The increasing importance of novel deep eutectic solvents as potential effective antimicrobials and other medicinal properties.World journal of microbiology & biotechnology · 2023Review
- Morphological Characterization ofPlants (Basel, Switzerland) · 2023Article
- Ready-to-Use Nutraceutical Formulations from Edible and Waste Organs of Algerian Artichokes.Foods (Basel, Switzerland) · 2022Article
- Selectivity Tuning by Natural Deep Eutectic Solvents (NADESs) for Extraction of Bioactive Compounds fromMolecules (Basel, Switzerland) · 2022Article
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12 authors.
Funding
Abstract
Natural deep eutectic solvents (NADES) are a new alternative to toxic organic solvents. Their constituents are primary metabolites, non-toxic, biocompatible and sustainable. In this study four selected NADES were applied for the extraction of two medicinal plants: Sideritis scardica, and Plantago major as an alternative to water-alcohol mixtures, and the antimicrobial and genotoxic potential of the extracts were studied. The extraction efficiency was evaluated by measuring the extracted total phenolics, and total flavonoids. Best extraction results for total phenolics for the studied plants were obtained with choline chloride-glucose 5:2 plus 30% water; but surprisingly these extracts were inactive against all tested microorganisms. Extracts with citric acid-1,2-propanediol 1:4 and choline chloride-glycerol 1:2 showed good activity against S. pyogenes, E. coli, S. aureus, and C. albicans. Low genotoxicity and cytotoxicity were observed for all four NADES and the extracts with antimicrobial activity. Our results confirm the potential of NADESs for extraction of bioactive constituents of medicinal plants and further suggest that NADES can improve the effects of bioactive extracts. Further studies are needed to clarify the influence of the studied NADES on the bioactivity of dissolved substances, and the possibility to use such extracts in the pharmaceutical and food industry.
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