ArticleGenome biology2020
Determinants of Staphylococcus aureus carriage in the developing infant nasal microbiome.
Article in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Prevalence of Streptococcus pneumoniae and Staphylococcus aureus co-colonization in healthy children under five years: a systematic review.BMC pediatrics · 2026Pooled it
- Exploring the microbial landscape of the nasopharynx in children: a systematic review of studies using next generation sequencing.Frontiers in microbiomes · 2023Pooled it
- A Double-blind Randomized Trial of Oral Chlorhexidine Gluconate for Treatment of OralOpen forum infectious diseases · 2026Trial
- Changes in nasal and throat microbiota composition during and after mupirocin and chlorhexidine decolonization treatment in asymptomatic methicillin-resistant Staphylococcus aureus carriers: a longitudinal observational study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026Observational
- Carbon regime structures functional trait trajectories during primary succession in microorganisms.The ISME journal · 2026Article
- The neonatal and maternal nasal microbiomes are compositionally diverse and functionally distinct within 24 hours of birth.Frontiers in cellular and infection microbiology · 2026Article
- Large-scale characterisation of the nasal microbiome redefines Staphylococcus aureus colonisation status.Nature communications · 2025Article
- Mechanisms of bacterial host-to-host transmission.Microbiology and molecular biology reviews : MMBR · 2025Review
- Nasopharyngeal microbiome composition by SARS-CoV-2 presence and severity.Scientific reports · 2025Article
- Role of the upper airway microbiota in respiratory virus and bacterial pathobiont dynamics in the first year of life.Nature communications · 2025Article
- Profiling the nasopharyngeal Microbiome in patients with community-acquired pneumonia caused by Streptococcus pneumoniae: diagnostic challenges and ecological insights.Medical microbiology and immunology · 2025Article
- Computational and in vitro evaluation of probiotic treatments for nasalProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Association of Neonatal and Maternal Nasal Microbiome Among Neonates in the Intensive Care Unit.Open forum infectious diseases · 2024Article
- Upper respiratory microbial communities of healthy populations are shaped by niche and age.Microbiome · 2024Article
- Upper respiratory microbial communities of healthy populations are shaped by niche and age.bioRxiv : the preprint server for biology · 2024Article
- Dolosigranulum pigrum: A promising nasal probiotic candidate.PLoS pathogens · 2024Article
- Unique microbial landscape in the human oropharynx during different types of acute respiratory tract infections.Microbiome · 2023Article
- Design and validation of Dolosigranulum pigrum specific PCR primers using the bacterial core genome.Scientific reports · 2023Article
- Formation of a biofilm matrix network shapes polymicrobial interactions.The ISME journal · 2023Article
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Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundStaphylococcus aureus is a leading cause of healthcare- and community-associated infections and can be difficult to treat due to antimicrobial resistance. About 30% of individuals carry S. aureus asymptomatically in their nares, a risk factor for later infection, and interactions with other species in the nasal microbiome likely modulate its carriage. It is thus important to identify ecological or functional genetic elements within the maternal or infant nasal microbiomes that influence S. aureus acquisition and retention in early life.
resultsWe recruited 36 mother-infant pairs and profiled a subset of monthly longitudinal nasal samples from the first year after birth using shotgun metagenomic sequencing. The infant nasal microbiome is highly variable, particularly within the first 2 months. It is weakly influenced by maternal nasal microbiome composition, but primarily shaped by developmental and external factors, such as daycare. Infants display distinctive patterns of S. aureus carriage, positively associated with Acinetobacter species, Streptococcus parasanguinis, Streptococcus salivarius, and Veillonella species and inversely associated with maternal Dolosigranulum pigrum. Furthermore, we identify a gene family, likely acting as a taxonomic marker for an unclassified species, that is significantly anti-correlated with S. aureus in infants and mothers. In gene content-based strain profiling, infant S. aureus strains are more similar to maternal strains.
conclusionsThis improved understanding of S. aureus colonization is an important first step toward the development of novel, ecological therapies for controlling S. aureus carriage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.