Observational studyBMC pregnancy and childbirth2020
Association between maternal cannabis use and birth outcomes: an observational study.
Observational study in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Birth, cognitive and behavioral effects of intrauterine cannabis exposure in infants and children: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2024Pooled it
- Birth Outcomes of Neonates Exposed to Marijuana in Utero: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Cohort Profile: The Ontario Birth Study (OBS).International journal of epidemiology · 2026Article
- The theory of planned behavior partly explains why adults with chronic musculoskeletal pain consider using medical cannabis for pain management.Scientific reports · 2026Article
- Meta-analysis of maternal and neonatal outcomes of cannabis use in pregnancy current to March 2024.Maternal health, neonatology and perinatology · 2025Review
- Linking pregnancy- and birth-related risk factors to a multivariate fusion of child cortical structure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Linking Pregnancy- and Birth-Related Risk Factors to a Multivariate Fusion of Child Cortical Structure.bioRxiv : the preprint server for biology · 2025Article
- Exploring Natural Analgesics for Chronic Pain Management: Cannabinoids and other Phytoconstituents.Current medicinal chemistry · 2025Review
- Estimating the effects of prenatal cannabis exposure on birth outcomes.The American journal on addictions · 2025Article
- Impact of prenatal exposure to delta 9-tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories.Pediatric obesity · 2025Article
- Substance and alcohol use in pregnant women attending antenatal care at a tertiary hospital in Johannesburg, South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- The longitudinal assessment of prenatal cannabis use on neonatal outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Cannabis exposure during pregnancy and perinatal outcomes: A cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Prenatal Exposure to Cannabis: Effects on Childhood Obesity and Cardiometabolic Health.Current obesity reports · 2024Review
- Maternal, Fetal and Neonatal Outcomes Related to Recreational Cannabis Use during Pregnancy: Analysis of a Real-World Clinical Data Warehouse between 2010 and 2019.International journal of environmental research and public health · 2023Article
- Cannabis-related diagnosis in pregnancy and adverse maternal and infant outcomes.Drug and alcohol dependence · 2021Article
- In Utero Exposure to Δ9-Tetrahydrocannabinol Leads to Postnatal Catch-Up Growth and Dysmetabolism in the Adult Rat Liver.International journal of molecular sciences · 2021Article
- Maternal Cannabis Use in the Perinatal Period: Data From the Pregnancy Risk Assessment Monitoring System Marijuana Supplement, 2016-2018.Journal of addiction medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundAs cannabis consumption is increasing globally, including among pregnant women, there is a critical need to understand the effects of cannabis on fetal development and birth outcomes. We had two objectives: to determine 1) the factors associated with self-reported cannabis use in the pre/early-pregnancy period, and 2) whether cannabis use is associated with low birth weight, preterm birth, or small size for gestational age (GA) infants.
methodsMaternal questionnaire and birth outcome data was gathered from 2229 women and 1778 singleton infants in the Ontario Birth Study, a hospital-based prospective cohort study (2013-2019). Women self-reported cannabis use within 3 months of learning their pregnancy status. Multivariable linear and logistic regression was conducted to 1) identify factors associated with cannabis use, and 2) determine the associations between cannabis use with the selected birth outcomes.
resultsCannabis use increased in the cohort over time. Women who reported cannabis use (N = 216) were more likely to be younger and more likely to use alcohol, tobacco, and prescription pain medication, although most did not. These women had infants born at lower average birth weights and had 2.0 times the odds of being small for GA (95% confidence interval: 1.3, 3.3) after multivariable adjustment for socioeconomic factors and other substance use.
conclusionOur results suggest that women who use cannabis around the time of conception have higher odds of having infants that are small for gestational age. Targeted clinical messaging may be most applicable to women actively trying to conceive.
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