Evidence map›Paper›PMID 33307933›Full record

Observational studyRenal failure2021

Clinical features and outcome of maintenance hemodialysis patients with COVID-19 from a tertiary nephrology care center in Romania.

Gabriel Stefan, Ana Maria Mehedinti, Iuliana Andreiana, Adrian Dorin Zugravu, Simona Cinca, Ruxandra Busuioc, Ioana Miler, Simona Stancu, Ligia Petrescu, Ioana Dimitriu and 6 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 5 pooled it
1.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Kidney involvement and anemia in COVID-19 infection.World journal of nephrology · 2025
    Review
  8. Article
  9. Article
  10. Clinical manifestations of COVID-19 infection in dialysis patients and protective effect of COVID-19 vaccine.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Gabriel Stefan"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Ana Maria Mehedinti"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Iuliana Andreiana"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Adrian Dorin Zugravu"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Simona Cinca"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Ruxandra Busuioc"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Ioana Miler"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Simona Stancu"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Ligia Petrescu"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Ioana Dimitriu"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Elena Moldovanu"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Diana Elena Crasnaru"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Georgeta Gugonea"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Valentin Georgescu"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Victor Dan Strambu"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Cristina Capusa"Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited information about the clinical characteristics, treatment and outcome of maintenance hemodialysis patients with COVID-19. Moreover, regional differences are also conceivable since the extend and severity of outbreaks varied among countries.

methodsIn this retrospective, observational, single-center study, we analyzed the clinical course and outcomes of 37 maintenance hemodialysis patients (median age 64 years, 51% men) hospitalized with COVID-19 from 24 March to 22 May 2020 as confirmed by real-time PCR.

resultsThe most common symptoms at admission were fatigue (51%), fever (43%), dyspnea (38%) and cough (35%). There were 59% mild/moderate patients and 41% severe/critical patients. Patients in the severe/critical group had a significantly higher atherosclerotic burden since diabetic kidney disease and vascular nephropathies were the most common primary kidney diseases and eighty percent of them had coronary heart disease. Also, Charlson comorbidity score was higher in this group. At admission chest X-ray, 46% had ground-glass abnormalities. Overall, 60% patients received hydroxychloroquine, 22% lopinavir-ritonavir, 11% tocilizumab, 24% systemic glucocorticoids, and 54% received prophylactic anticoagulation. Seven (19%) patients died during hospitalization and 30 were discharged. The main causes of death were cardiovascular (5 patients) and respiratory distress syndrome (2 patients). In Cox regression analysis, lower oxygen saturation, anemia and hypoalbuminemia at admission were associated with increased mortality.

conclusionsIn conclusion, we observed a high mortality rate among maintenance hemodialysis patients hospitalized for COVID-19. Anemia, lower serum albumin and lower basal oxygen saturation at admission were factors associated with poor prognosis.

Indexed as

Renal DialysisAgedCause of DeathComorbidityCOVID-19FemaleHospital MortalityHumansKidney Failure, ChronicMaleMiddle AgedOxygenPatient AdmissionPrognosisRetrospective StudiesRisk FactorsOxygenSerum Albumin, Humanchronic hemodialysisclinical featuresCOVID-19mortality

Identifiers

PMID33307933
PMCPMC7745841
OpenAlexW3111991481

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.