Evidence map›Paper›PMID 33307873›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking.

Alberto Cornejo, Julio Caballero, Mario Simirgiotis, Vanessa Torres, Luisa Sánchez, Nicolás Díaz, Marcela Guimaraes, Marcos Hernández, Carlos Areche, Sergio Alfaro and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Alberto CornejoEscuela de Tecnología Médica, Facultad de Medicina, Universidad Andres Bello, Laboratorio Catem V, Santiago, Chile.
Julio CaballeroDepartamento de Bioinformática, Facultad de Ingeniería, Centro de Bioinformática, Simulación y Modelado (CBSM), Universidad de Talca, Talca, Chile.
Mario SimirgiotisFacultad de Ciencias, Instituto de Farmacia, Universidad Austral de Chile, Valdivia, Chile.ORCID https://orcid.org/0000-0003-4552-3123
Vanessa TorresEscuela de Tecnología Médica, Facultad de Medicina, Universidad Andres Bello, Laboratorio Catem V, Santiago, Chile.
Luisa SánchezEscuela de Tecnología Médica, Facultad de Medicina, Universidad Andres Bello, Laboratorio Catem V, Santiago, Chile.
Nicolás DíazEscuela de Tecnología Médica, Facultad de Medicina, Universidad Andres Bello, Laboratorio Catem V, Santiago, Chile.
Marcela GuimaraesDepartment of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil.
Marcos HernándezDepartamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
Carlos ArecheDepartamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-5246-1368
Sergio AlfaroDoctorado en Ciencias, mención Modelado de Sistemas Químicos y Biológicos, Centro de Bioinformática, Simulación y Modelado (CBSM), Facultad de Ingeniería, Universidad de Talca, Talca, Chile.
Leonardo CaballeroDepartamento de Física and Soft Matter Research Center, SMAT-C, Universidad de Santiago, Santiago, Chile.
Francisco MeloDepartamento de Física and Soft Matter Research Center, SMAT-C, Universidad de Santiago, Santiago, Chile.
Universidad Andrés Bello · CLUniversidad de Santiago de Chile · CLUniversity of Chile · CLUniversity of Talca · CLAustral University of Chile · CLUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes

Indexed as

Molecular Docking Simulationalpha-SynucleinAnimalsBinding SitesDammaranesDose-Response Relationship, DrugMagnoliopsidaMiceMolecular ConformationProtein AggregatesStructure-Activity RelationshipTriterpenesTumor Cells, Culturedalpha-SynucleinDammaranesProtein AggregatesTriterpenesdrug targetnatural compounds modifiersoligomersParkinson’s disease

Identifiers

PMID33307873
PMCPMC7738290
OpenAlexW3112926179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.