Evidence map›Paper›PMID 33307825›Full record

ArticleNutrition and cancer2021

Pretreatment Dietary Patterns, Serum Carotenoids and Tocopherols Influence Tumor Immune Response in Head and Neck Squamous Cell Carcinoma.

Ilona Argirion, Anna E Arthur, Katie R Zarins, Emily Bellile, Sylvia L Crowder, Lahin Amlani, Jeremy Mg Taylor, Greg T Wolf, Jonathan McHugh, Ariane Nguyen and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition and cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Ilona ArgirionDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4925-5296
Anna E ArthurDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Katie R ZarinsDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA.
Emily BellileDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Sylvia L CrowderDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Lahin AmlaniDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jeremy Mg TaylorDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Greg T WolfDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jonathan McHughPathology, The University of Michigan Health System, Ann Arbor, Michigan, USA.
Ariane NguyenDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-5556-4258
Alison M MondulDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Laura S RozekDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan Head and Neck SPORE Program
University of Michigan · USCarle Foundation Hospital · USUniversity of Illinois Urbana-Champaign · US

Funding

Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOR, JACQUES EDUARDO · 2002 to 2013
$25.3M
ENVIRONMENTAL TOXICOLOGY PRE/POST DOCTORAL RES.TRAININGT32ES007062 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 1985 to 2026
$10.5M
NCI NIH HHS P50 CA097248NIEHS NIH HHS T32 ES007062
6 · The paper itself

Abstract

backgroundTumor infiltrating lymphocytes (TILs) aid in informing treatment for head and neck squamous cell carcinoma (HNSCC). Nevertheless, little is known about the role of diet on TILs.

methodsImmunohistologic expression of CD4, CD8, CD68, CD103, CD104 and FOXP3 were assessed in tissue microarrays from 233 previously untreated HNSCC patients. Associations between these markers and pretreatment dietary patterns were evaluated using linear regression. Associations between baseline serum carotenoids, tocopherols and TILs were assessed using logistic regression. Cox models evaluated the association between diet and TILs on overall and recurrence-free survival.

resultsConsumption of a Western dietary pattern was associated with lower CD8+ and FOXP3+ infiltrates (p-value:0.03 and 0.02, respectively). Multivariable logistic regression models demonstrated significantly higher CD8+ (OR:2.21;p-value:0.001) and FOXP3+ (OR:4.26;p-value:<0.0001) among patients with high gamma tocopherol. Conversely, high levels of xanthophylls (OR:0.12;p-value:<0.0001), lycopene (OR:0.36;p-value:0.0001) and total carotenoids(OR:0.31;p-value: <0.0001) were associated with significantly lower CD68+. Among those with high CD4+ (HR:1.77;p-value:0.03), CD68+ (HR:2.42;p-value:0.004), CD103+ (HR:3.64;p-value:0.03) and FOXP3+ (HR:3.09;p-value:0.05), having a high Western dietary pattern increased the risk of overall mortality when compared to a low Western dietary pattern.

conclusionDietary patterns and serum carotenoids may play an important role in modifying TILs, and ultimately, outcome after diagnosis with HNSCC.

Indexed as

Head and Neck NeoplasmsTocopherolsCarotenoidsCD8-Positive T-LymphocytesHumansImmunityPrognosisSquamous Cell Carcinoma of Head and NeckCarotenoidsTocopherols

Identifiers

PMID33307825
PMCPMC9675403
OpenAlexW3113042932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.