ArticleExperimental biology and medicine (Maywood, N.J.)2021
Functional intrinsic optical signal imaging for objective optoretinography of human photoreceptors.
Article in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable.Biomedical optics express · 2026Article
- Functional OCT with parfocal retinal stimulation enables multi-site optoretinography under a single dark adaptation.Biomedical optics express · 2026Article
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- Whole retina light-evoked optoretinography (ORG) under different retina hydration levels: modeling of Bruch's membrane ORGs.Biomedical optics express · 2025Article
- Review
- Polarization optical coherence tomography optoretinography: verifying light-induced photoreceptor outer segment shrinkage and subretinal space expansion.Neurophotonics · 2025Article
- From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases.Diagnostics (Basel, Switzerland) · 2024Review
- Optical Coherence Tomography Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Early Central Cone Photoreceptor Dysfunction in Retinal Dystrophies.Translational vision science & technology · 2024Article
- Light-adapted flicker-optoretinography based on raster-scan optical coherence tomography towards clinical translation.Biomedical optics express · 2024Article
- Unraveling the functional signals of rods and cones in the human retina: separation and analysis.Frontiers in ophthalmology · 2024Article
- Intrinsic signal optoretinography revealing AD-induced retinal photoreceptor hyperexcitability before a detectable morphological abnormality.Optics letters · 2023Article
- Rotational Distortion and Compensation in Optical Coherence Tomography with Anisotropic Pixel Resolution.Bioengineering (Basel, Switzerland) · 2023Article
- Article
- Fast and slow light-induced changes in murine outer retina optical coherence tomography: complementary high spatial resolution functional biomarkers.PNAS nexus · 2022Article
- Quantification of intrinsic optical signals in the outer human retina using optical coherence tomography.Annals of the New York Academy of Sciences · 2022Article
- Intrinsic signal optoretinography of dark adaptation kinetics.Scientific reports · 2022Article
- Functional Optical Coherence Tomography for Intrinsic Signal Optoretinography: Recent Developments and Deployment Challenges.Frontiers in medicine · 2022Review
- Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system.Biomedical optics express · 2021Article
- Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography.Journal of biomedical optics · 2021Review
- Functional optoretinography: concurrent OCT monitoring of intrinsic signal amplitude and phase dynamics in human photoreceptors.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Functional mapping of photoreceptor physiology is important for better disease diagnosis and treatment assessment. Fast intrinsic optical signal (IOS), which arises before light-evoked pupillary response, promises a unique biomarker of photoreceptor physiology for objective optoretinography with high resolution. This study is to test the feasibility of non-mydriatic IOS mapping of retinal photoreceptors in awake human. Depth-resolved optical coherence tomography verified outer segment (OS) as the anatomic origin of fast photoreceptor-IOS. Dynamic IOS changes are primarily confined at OS boundaries connected with inner segment and retinal pigment epithelium, supporting transient OS shrinkage due to phototransduction process as the mechanism of the fast photoreceptor-IOS response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.