ArticleCartilage2021
BMP2 Is Required for Postnatal Maintenance of Osteochondral Tissues of the Temporomandibular Joint.
Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Energy metabolism dysfunction and therapeutic strategies for treating temporomandibular disorders.Frontiers in medicine · 2025Review
- BMP2 rs1005464 is associated with mandibular condyle size variation.Scientific reports · 2024Article
- Article
- Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced byJournal of orthopaedic translation · 2023Article
- A novel approach to establishing a temporomandibular joint fibrocartilage cell line.Journal of dental sciences · 2022Article
- Exosome-delivered BMP-2 and polyaspartic acid promotes tendon bone healing in rotator cuff tear via Smad/RUNX2 signaling pathway.Bioengineered · 2022Article
- Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection.Frontiers in physiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveBone morphogenetic protein 2 (BMP2) plays important roles in cartilage growth and development. Paradoxically, elevated levels of BMP2 leads to hypertrophic differentiation and osteoarthritis of cartilage. We examined the
designThree-week-old
resultsConditional deletion of BMP2 caused breakage of the cartilage integrity in the mandibular condyle of mice from both age groups, accompanied by a decrease in cartilage thickness, matrix synthesis, mineralization, chondrocyte proliferation, and increased expression of degeneration markers, while the effects at articular cartilage were not significant.
conclusionsIn conclusion, BMP2 is essential for postnatal maintenance of the osteochondral tissues of the mandibular condyle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.