ArticlePloS one2020
RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Circadian and photoperiodic control of melatonin inBiochemistry and biophysics reports · 2025Article
- Female membrane proteins regulate postmating ovulation inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.Development (Cambridge, England) · 2023Article
- Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.Development (Cambridge, England) · 2023Article
- RNAi-mediated knockdown of two orphan G protein-coupled receptors reduces fecundity in the yellow fever mosquitoFrontiers in insect science · 2023Article
- A single-cell transcriptomic atlas tracking the neural basis of division of labour in an ant superorganism.Nature ecology & evolution · 2022Article
- Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis.Development (Cambridge, England) · 2022Article
- Cell lines derived from the small hive beetle, Aethina tumida, express insecticide targets.In vitro cellular & developmental biology. Animal · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Reproduction is highly sensitive to changes in physiology and the external environment. Neuropeptides are evolutionarily conserved signaling molecules that regulate multiple physiological processes. However, the potential reproductive roles of many neuropeptide signaling pathways remain underexplored. Here, we describe the results of RNAi-based screens in Drosophila melanogaster to identify neuropeptides/neuropeptide receptors with potential roles in oogenesis. The screen read-outs were either the number of eggs laid per female per day over time or fluorescence microscopy analysis of dissected ovaries. We found that the orphan neuropeptide receptor encoded by moody (homologous to mammalian melatonin receptors) is likely required in somatic cells for normal egg production and proper germline stem cell maintenance. However, the egg laying screens had low signal-to-noise ratio and did not lead to the identification of additional candidates. Thus, although egg count assays might be useful for large-scale screens to identify oogenesis regulators that result in dramatic changes in oogenesis, more labor-intensive microscopy-based screen are better applicable for identifying new physiological regulators of oogenesis with more subtle phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.