ArticleNature2021
Genetic mechanisms of critical illness in COVID-19.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05336851 (Emergency PanorOmic Wide Association Study in Respiratory Infectious Disease), which is not on this map. Cited by 896 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
896citing papers in PubMed, 5 pooled it
97.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Emergency PanorOmic Wide Association Study in Respiratory Infectious Disease (ePWAS-RID)
Who cites it
896 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,484 citations in OpenAlex.
- Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies Pathways for Host-Directed Therapeutic Targeting.The Journal of infectious diseases · 2025Pooled it
- Challenges in interpreting Mendelian randomization studies with a disease as the exposure: Using COVID-19 liability studies as an exemplar.European journal of human genetics : EJHG · 2025Pooled it
- Sex-stratified genome-wide meta-analysis identifies novel loci for cognitive decline in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Meta-analysis of Transcriptomic Data from Lung Autopsy and Cellular Models of SARS-CoV-2 Infection.Biochemical genetics · 2024Pooled it
- Canadian COVID-19 host genetics cohort replicates known severity associations.PLoS genetics · 2024Pooled it
- Genetic factors associated with COVID-19 severity and mortality: TYK2 and NOTCH4.Biomedical reports · 2026Article
- Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice.Genetics · 2026Article
- The Neanderthal-Derived 3p21 Haplotype at LZTFL1 in Modern-Day Moroccans Is Associated With COVID-19 Severity and Further Suggests the Presence of Neanderthals in North Africa.International journal of immunogenetics · 2026Article
- Trop-1/EpCAM Thr115 is a driver of hyperproliferative cell repair and of severe lung damage in COVID-19.iScience · 2026Article
- Functional diversity of natural humanScience advances · 2026Article
- Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.The Journal of clinical investigation · 2026Article
- COVID-19 mRNA Vaccines as Antigen-Agnostic Immunomodulators: A Repurposing Perspective.Medical sciences (Basel, Switzerland) · 2026Review
- Integrated Inflammatory, Thrombo-Inflammatory, Redox and Soluble IFNAR2 Profiling During Hospitalization for COVID-19: An Exploratory Observational Cohort Study.Journal of clinical medicine · 2026Article
- Article
- Common genetic mechanisms between obesity and COVID-19 severity: unravelling pleiotropic loci and biological pathways.Royal Society open science · 2026Article
- β-Cell Dysfunction in COVID-19 and Post-COVID Syndrome: Molecular Mechanisms Linking Inflammation, Oxidative Stress, and Insulin Secretion.International journal of molecular sciences · 2026Review
- Disentangling Shared and Differential Genetic Architectures Between COVID-19 and Other Respiratory Disorders-A Genome-Wide Multi-Omics Framework.International journal of molecular sciences · 2026Article
- Integrating single-cell sQTL mapping with deep-learning splicing prediction identifies causal variants under influenza infection.Genome biology · 2026Article
- Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Identification and functional characterization of regulatory variants in DPP9 associated with COVID-19 severity.Genome medicine · 2026Article
836 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
72 authors at 17 institutions in 9 countries.
Erola Pairo-Castineira *Roslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2423-3090
Sara Clohisey *Roslin Institute, University of Edinburgh, Edinburgh, UK.
Lucija Klaric *MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3105-8929
Andrew D Bretherick *MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9258-3140
Konrad Rawlik *Roslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0010-370X
Dorota PaskoGenomics England, London, UK.
Susan WalkerGenomics England, London, UK.ORCID http://orcid.org/0000-0002-5016-6426
Nick ParkinsonRoslin Institute, University of Edinburgh, Edinburgh, UK.
Max Head FourmanRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7381-2278
Clark D RussellRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9873-8243
James FurnissRoslin Institute, University of Edinburgh, Edinburgh, UK.
Anne RichmondMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Elvina GountounaCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7870-2780
Nicola WrobelEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.
David HarrisonIntensive Care National Audit & Research Centre, London, UK.
Bo WangRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1580-797X
Yang WuInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-0128-7280
Alison MeynertMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Fiona GriffithsRoslin Institute, University of Edinburgh, Edinburgh, UK.
Wilna OosthuyzenRoslin Institute, University of Edinburgh, Edinburgh, UK.
Athanasios KousathanasGenomics England, London, UK.ORCID http://orcid.org/0000-0001-6265-6521
Loukas MoutsianasGenomics England, London, UK.ORCID http://orcid.org/0000-0001-5453-345X
Zhijian YangBiostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Ranran ZhaiBiostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0002-5834-9120
Chenqing ZhengBiostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Graeme GrimesMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Rupert BealeThe Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-6705-8560
Jonathan MillarRoslin Institute, University of Edinburgh, Edinburgh, UK.
Barbara ShihRoslin Institute, University of Edinburgh, Edinburgh, UK.
Sean KeatingIntensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-8552-5604
Marie ZechnerRoslin Institute, University of Edinburgh, Edinburgh, UK.
Chris HaleyRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9811-0210
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1249-6106
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Jian YangSchool of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0003-2001-2474
Julian KnightWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0377-5536
Charlotte SummersDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7269-2873
Manu Shankar-HariDepartment of Intensive Care Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-5338-2538
Paul KlenermanWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Lance TurtleNIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-0778-1693
Antonia HoMRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Shona C MooreNIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-8610-2806
Charles HindsWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-5094-8324
Peter HorbyCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Alistair NicholClinical Research Centre at St Vincent's University Hospital, University College Dublin, Dublin, Ireland.
David MasloveDepartment of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, Ontario, Canada.
Lowell LingDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Danny McAuleyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0002-3283-1947
Hugh MontgomeryUCL Centre for Human Health and Performance, University College London, London, UK.ORCID http://orcid.org/0000-0001-8797-5019
Timothy WalshIntensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
Alexandre C PereiraFaculty of Medicine, University of São Paulo, São Paulo, Brazil.
Alessandra RenieriMedical Genetics, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0002-0846-9220
GenOMICC Investigators
ISARIC4C Investigators
COVID-19 Human Genetics Initiative
23andMe Investigators
BRACOVID Investigators
Gen-COVID Investigators
Xia ShenBiostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0003-4390-1979
Chris P PontingMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0202-7816
Angie FawkesEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Albert TenesaRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4884-4475
Mark CaulfieldGenomics England, London, UK.ORCID http://orcid.org/0000-0001-9295-3594
Richard ScottGenomics England, London, UK.
Kathy RowanIntensive Care National Audit & Research Centre, London, UK.ORCID http://orcid.org/0000-0001-8217-5602
Lee MurphyEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6467-7449
Peter J M OpenshawNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7220-2555
Malcolm G SempleNIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-9700-0418
Andrew LawRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1868-2364
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4991-3797
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
J Kenneth BaillieRoslin Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.ORCID http://orcid.org/0000-0001-5258-793X
Roslin Institute · GBWestern General Hospital · GBSun Yat-sen University · CNCentre for Human Genetics · GBGenomics England · GBUniversity of Liverpool · GBQueen Mary University of London · GBQueen's University Belfast · GBUniversity College Dublin · IEUniversity of Siena · ITChinese University of Hong Kong · HKEdinburgh Royal Infirmary · GBImperial College Healthcare NHS Trust · GBKing's College London · GBThe Francis Crick Institute · GBUniversidade de São Paulo · BRWestlake University · CN
Funding
Medical Research Council G0701075Medical Research Council G0901254Medical Research Council G1001253Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MC_PC_19025Medical Research Council MC_PC_19026Medical Research Council MC_PC_19056Medical Research Council MC_PC_19059Medical Research Council MC_PC_20004Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00007/15Medical Research Council MC_UU_12008/1Medical Research Council MC_UU_12014/9Medical Research Council MR/J004758/1Medical Research Council MR/K01417X/1Medical Research Council MR/L501542/1Medical Research Council MR/M00869X/2Medical Research Council MR/M009203/1Medical Research Council MR/N02995X/1Medical Research Council MR/P015514/1Medical Research Council MR/R026408/1Medical Research Council MR/S006753/1Medical Research Council MR/S032304/1Parkinson's UK G-0907Parkinson's UK G-1307Wellcome Trust 103258/Z/13/AWellcome Trust 104036/Z/14/ZWellcome Trust 109965/Z/15/ZWellcome Trust 205228/Z/16/ZWellcome Trust 210561/Z/18/ZWellcome Trust 215091/Z/18/ZWellcome Trust 216767/Z/19/ZWellcome Trust MR/R026408/1
Abstract
Host-mediated lung inflammation is present
Indexed as
Critical Illness2',5'-Oligoadenylate SynthetaseChromosomes, Human, Pair 12Chromosomes, Human, Pair 19Chromosomes, Human, Pair 21COVID-19Critical CareDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDrug RepositioningFemaleGenome-Wide Association StudyHumansInflammationLungMaleMultigene Family2',5'-Oligoadenylate SynthetaseCCR2 protein, humanDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDPP9 protein, humanIFNAR2 protein, humanOAS1 protein, humanOAS2 protein, humanOAS3 protein, humanReceptor, Interferon alpha-betaReceptors, CCR2TYK2 KinaseTYK2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT05336851ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.