Evidence map›Paper›PMID 33307301›Full record

ArticleDrug and alcohol dependence2021

Emergency department patients with untreated opioid use disorder: A comparison of those seeking versus not seeking referral to substance use treatment.

Edouard Coupet, Gail D'Onofrio, Marek Chawarski, E J Edelman, Patrick G O'Connor, Patricia Owens, Shara Martel, David A Fiellin, Ethan Cowan, Lynne Richardson and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03023930 (Opioid Use Disorder in the Emergency Department), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03023930 nacompletednot on this map

Opioid Use Disorder in the Emergency Department: Clinical Trials Network-0069

TypeinterventionalSponsorYale UniversityRan2017 to 2022Enrolled1,731ConditionsOpioid Use DisorderArmsStandard Dissemination Practice, Implementation Facilitation (IF)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Racial and ethnic disparities in emergency department-initiated buprenorphine across five health care systems.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Edouard CoupetYale School of Medicine, Department of Emergency Medicine, New Haven, CT, USA; Yale Program in Addiction Medicine, New Haven, CT, USA. Electronic address: edouard.coupet@yale.edu.
Gail D'OnofrioYale School of Medicine, Department of Emergency Medicine, New Haven, CT, USA; Yale Program in Addiction Medicine, New Haven, CT, USA.
Marek ChawarskiYale School of Medicine, Department of Emergency Medicine, New Haven, CT, USA; Yale Program in Addiction Medicine, New Haven, CT, USA; Yale School of Medicine, Department of Internal Medicine, New Haven, CT, USA.
E J EdelmanYale Program in Addiction Medicine, New Haven, CT, USA; Yale School of Medicine, Department of Internal Medicine, New Haven, CT, USA.
Patrick G O'ConnorYale Program in Addiction Medicine, New Haven, CT, USA; Yale School of Medicine, Department of Internal Medicine, New Haven, CT, USA.
Patricia OwensYale School of Medicine, Department of Emergency Medicine, New Haven, CT, USA.
Shara MartelYale School of Medicine, Department of Emergency Medicine, New Haven, CT, USA.
David A FiellinYale School of Medicine, Department of Emergency Medicine, New Haven, CT, USA; Yale Program in Addiction Medicine, New Haven, CT, USA; Yale School of Medicine, Department of Internal Medicine, New Haven, CT, USA; Yale School of Public Health, Department of Health Policy and Management, New Haven, CT, USA.
Ethan CowanIcahn School of Medicine at Mount Sinai, Department of Emergency Medicine, New York, NY, USA.
Lynne RichardsonIcahn School of Medicine at Mount Sinai, Department of Emergency Medicine, New York, NY, USA.
Kristen HuntleyCenter for Clinical Trial Network, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Lauren K WhitesideUniversity of Washington, Department of Emergency Medicine, Seattle, WA, USA.
Michael S LyonsUniversity of Cincinnati, Department of Emergency Medicine, Cincinnati, OH, USA.
Richard E RothmanJohns Hopkins University School of Medicine, Department of Emergency Medicine, Baltimore, MD, USA.
Michael PantalonYale School of Medicine, Department of Emergency Medicine, New Haven, CT, USA.
Kathryn HawkYale School of Medicine, Department of Emergency Medicine, New Haven, CT, USA; Yale Program in Addiction Medicine, New Haven, CT, USA.

Funding

The National Drug Abuse Treatment Clinical Trials NetworkUG1DA015831 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Roger D. Weiss · 2015 to 2026
$110.8M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan · 1998 to 2026
$38.9M
Clinical Trials Network: Pacific Northwest Node (CTN-0082, -0131, -0139 and dissemination library)UG1DA013714 · NIDA · UNIVERSITY OF WASHINGTON · PI Mary Akiko Hatch, John M. Roll · 2015 to 2026
$19.8M
Yale Drug use, Addiction and HIV Research Scholars (DAHRS)K12DA033312 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Patrick O'Connor · 2013 to 2026
$7.2M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K12 DA033312NIDA NIH HHS P30 DA011041NIDA NIH HHS UG1 DA013714NIDA NIH HHS UG1 DA015831
6 · The paper itself

Abstract

BACKGROUND Little is known regarding the sociodemographic and clinical characteristics of emergency department (ED) patients with untreated opioid use disorder (OUD) and the relationship of those characteristics with whether they were seeking a referral to substance use treatment at the time of their ED visit. METHODS Using data collected from 2/2017-1/2019 from participants enrolled in Project ED Health (CTN-0069), we conducted a cross-sectional analysis of patients with untreated moderate to severe OUD presenting to one of four EDs in Baltimore, New York City, Cincinnati, or Seattle. Sociodemographic and clinical correlates, and International Classification of Diseases Tenth Revision (ICD-10) diagnosis codes related to opioid withdrawal, injection-related infection, other substance use, overdose, and OUD of those seeking and not seeking a referral to substance use treatment on presentation were compared using univariate analyses. RESULTS Among 394 study participants, 15.2 % (60/394) came to the ED seeking a referral to substance use treatment. No differences in age, gender, education, health insurance status or housing stability were detected between those seeking and not seeking referral to substance use treatment. Those seeking a referral to substance use treatment were less likely to have urine toxicology testing positive for amphetamine [17 % (10/60) vs 31 % (104/334), p = 0.023] and methamphetamine [23 % (14/60) vs 40 % (132/334), p = 0.017] compared to those not seeking a referral. CONCLUSION Most patients with untreated OUD seen in the EDs were not seeking a referral to substance use treatment. Active identification, treatment initiation, and coding may improve ED efforts to address untreated OUD.

Indexed as

AdultAmphetamineBaltimoreCross-Sectional StudiesDrug OverdoseEmergency Service, HospitalFemaleHumansInternational Classification of DiseasesMaleMethamphetamineMiddle AgedNew York CityOpioid-Related DisordersReferral and ConsultationSurveys and QuestionnairesAmphetamineMethamphetamineBrief interventionEmergency departmentOpioidsReferralScreeningSubstance useTreatment

Identifiers

PMID33307301
PMCPMC8110210

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.