ArticleGenetics and molecular biology2020
Differential expression of antioxidant system genes in honey bee (Apis mellifera L.) caste development mitigates ROS-mediated oxidative damage in queen larvae.
Article in Genetics and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Tissue-specific mitochondrial pathway remodeling linked to longevity in honeybee queens.PloS one · 2026Article
- Integrating WGCNA, TCN, and Alternative Splicing to Map Early Caste Programs in Day-2 Honeybee Larvae.Genes · 2025Article
- Analysis of Panels of Chemical Biomarkers in the Honeybee in Hemolymph and Fat Body in Response to Physiological and Environmental Factors.Metabolites · 2025Review
- Antioxidant Activities in the Hemolymph and Fat Body of Physiologically and Prematurely Aging Bees (Antioxidants (Basel, Switzerland) · 2025Article
- Changes in the Activities of Antioxidant Enzymes in the Fat Body and Hemolymph ofAntioxidants (Basel, Switzerland) · 2025Article
- Queen bee gut microbiota extends honeybee lifespan by inhibiting insulin signaling.Applied and environmental microbiology · 2024Article
- The Juvenile-Hormone-Responsive FactorBiomolecules · 2023Article
- Article
- Activities of Antioxidant and Proteolytic Systems and Biomarkers in the Fat Body and Hemolymph of YoungAnimals : an open access journal from MDPI · 2022Article
- Antioxidation Defenses ofAnimals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of morphological differences between the castes of social bees is triggered by dietary regimes that differentially activate nutrient-sensing pathways and the endocrine system, resulting in differential gene expression during larval development. In the honey bee, Apis mellifera, mitochondrial activity in the larval fat body has been postulated as a link that integrates nutrient-sensing via hypoxia signaling. To understand regulatory mechanisms in this link, we measured reactive oxygen species (ROS) levels, oxidative damage to proteins, the cellular redox environment, and the expression of genes encoding antioxidant factors in the fat body of queen and worker larvae. Despite higher mean H2O2 levels in queens, there were no differences in ROS-mediated protein carboxylation levels between the two castes. This can be explained by their higher expression of antioxidant genes (MnSOD, CuZnSOD, catalase, and Gst1) and the lower ratio between reduced and oxidized glutathione (GSH/GSSG). In worker larvae, the GSG/GSSH ratio is elevated and antioxidant gene expression is delayed. Hence, the higher ROS production resulting from the higher respiratory metabolism in queen larvae is effectively counterbalanced by the up-regulation of antioxidant genes, avoiding oxidative damage. In contrast, the delay in antioxidant gene expression in worker larvae may explain their endogenous hypoxia response.
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Registered trials
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