Evidence map›Paper›PMID 33306721›Full record

Trial reportPloS one2020

Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection.

Laurie G Jacobs, Elli Gourna Paleoudis, Dineen Lesky-Di Bari, Themba Nyirenda, Tamara Friedman, Anjali Gupta, Lily Rasouli, Marygrace Zetkulic, Bindu Balani, Chinwe Ogedegbe and 4 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05060562 (Predictors of the Occurrence of Post Coronavirus Disease Syndrome Among COVID-19 Patients in Indonesia), which is not on this map. Cited by 177 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 20 pooled it
24.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05060562 completednot on this mapstarted 2021, after this paper: background citation

Predictors of the Occurrence of Post Coronavirus Disease Syndrome Among COVID-19 Patients in Indonesia

TypeobservationalSponsorHasanuddin UniversityRan2021 to 2023Enrolled6,051ConditionsCovid19ArmsCOVID 19 positive, COVID 19 negative
3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 20 syntheses or guidelines pooled it, 328 citations in OpenAlex.

  1. Diagnosis and Treatment of Adult Patients with Cough.Respiration; international review of thoracic diseases · 2025
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  5. SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
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  7. Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022
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  11. Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Pooled it
  12. Fatigue Symptoms Associated With COVID-19 in Convalescent or Recovered COVID-19 Patients; a Systematic Review and Meta-Analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022
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117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Laurie G JacobsDepartment of Internal Medicine, Hackensack Meridian School of Medicine, Nutley, New Jersey, United States of America.ORCID 0000-0003-3609-2157
Elli Gourna PaleoudisOffice of Research Administration, Hackensack Meridian Health, Edison, New Jersey, United States of America.
Dineen Lesky-Di BariDepartment of Research, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, New Jersey, United States of America.
Themba NyirendaOffice of Research Administration, Hackensack Meridian Health, Edison, New Jersey, United States of America.
Tamara FriedmanOffice of Research Administration, Hackensack Meridian Health, Edison, New Jersey, United States of America.
Anjali GuptaDepartment of Internal Medicine, Hackensack Meridian School of Medicine, Nutley, New Jersey, United States of America.
Lily RasouliDepartment of Internal Medicine, Hackensack University Medical Center, Hackensack, New Jersey, United States of America.
Marygrace ZetkulicDepartment of Internal Medicine, Hackensack Meridian School of Medicine, Nutley, New Jersey, United States of America.
Bindu BalaniDepartment of Internal Medicine, Hackensack Meridian School of Medicine, Nutley, New Jersey, United States of America.
Chinwe OgedegbeDepartment of Emergency Medicine, Hackensack Meridian School of Medicine, Nutley, New Jersey, United States of America.
Harinder BawaDepartment of Internal Medicine, Hackensack Meridian School of Medicine, Nutley, New Jersey, United States of America.
Lauren BerrolDepartment of Anesthesiology, Hackensack University Medical Center, Hackensack, New Jersey, United States of America.
Nabiha QureshiDepartment of Internal Medicine, Hackensack University Medical Center, Hackensack, New Jersey, United States of America.
Judy L AschnerDepartment of Pediatrics, Hackensack Meridian School of Medicine, Nutley, New Jersey, United States of America.
Hackensack University Medical Center · USHackensack Meridian Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCharacterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function. METHODS AND

findingsThis prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI: 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI: 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI: 0.016, 0.193], p <0.0001), mental health (43.7%, OR 0.093 [95% CI: 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI: 0.031, 0.291], p<0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI: 2·216, 33·884], p = 0·0019).

conclusionsCOVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services.

Indexed as

COVID-19HospitalizationMental HealthQuality of LifeSARS-CoV-2AdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNew JerseyProspective StudiesTime Factors

Identifiers

PMID33306721
PMCPMC7732078
OpenAlexW3110811149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.