Evidence map›Paper›PMID 33306414›Full record

Trial reportExpert opinion on investigational drugs2021

Results from a biomarker study to accompany a phase II trial of RRx-001 with reintroduced platinum-based chemotherapy in relapsed small cell carcinoma.

Min-Jung Lee, Yusuke Tomita, Akira Yuno, Sunmin Lee, Nacer E Abrouk, Bryan Oronsky, Scott Caroen, Jane B Trepel

Open access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Expert opinion on investigational drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. [Tumor-associated Macrophage: 
Emerging Targets for Modulating the Tumor Microenvironment].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Min-Jung LeeDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, MD, USA.
Yusuke TomitaDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-9680-7559
Akira YunoDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, MD, USA.
Sunmin LeeDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, MD, USA.
Nacer E AbroukDepartment of Clinical Research, Clinical Trial Innovations , Mountain View, CA, USA.
Bryan OronskyDepartment of Clinical Research, EpicentRx, Inc , La Jolla, CA, USA.
Scott CaroenDepartment of Clinical Research, EpicentRx, Inc , La Jolla, CA, USA.
Jane B TrepelDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, MD, USA.
National Institutes of Health · USClinical Innovations (United States) · US

Funding

Signal Transduction Events and the Regulation of Cell GrowthZICSC006743 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI TREPEL, JANE B · 2009 to 2023
$13.8M
Intramural NIH HHS ZIC SC006743
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsAzetidinesCarboplatinCisplatinDisease ProgressionEtoposideHLA-DR AntigensHumansLung NeoplasmsMembrane GlycoproteinsNitro CompoundsReceptors, ImmunologicSmall Cell Lung CarcinomaTime FactorsTreatment OutcomeTumor-Associated MacrophagesAzetidinesCarboplatinCisplatinEtoposideHLA-DR AntigensMembrane GlycoproteinsMRC1 protein, humanNitro CompoundsReceptors, ImmunologicRRx-001biomarkerschemotherapyImmunotherapymacrophage repolarizationplatinum doubletRRx-001small cell carcinoma

Identifiers

PMID33306414
PMCPMC9169989
OpenAlexW3112395603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.