Evidence map›Paper›PMID 33306381›Full record

ArticleThe journal of physical chemistry. B2020

Direct Observations of Silver Nanowire-Induced Frustrated Phagocytosis among NR8383 Lung Alveolar Macrophages.

Evgeny Ogorodnik, Arpad Karsai, Kang-Hsin Wang, Fu-Tong Liu, Su Hao Lo, Kent E Pinkerton, Benjamin Gilbert, Dominik R Haudenschild, Gang-Yu Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Evgeny OgorodnikBiophysics Graduate Group, University of California, Davis, California 95616, United States.
Arpad KarsaiDepartment of Chemistry, University of California, Davis, California 95616, United States.
Kang-Hsin WangDepartment of Dermatology, University of California Davis, School of Medicine, Sacramento, California 95817, United States.
Fu-Tong LiuInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Su Hao LoDepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, California 95817, United States.
Kent E PinkertonDepartment of Pediatrics, University of California Davis, School of Medicine, Sacramento, California 95817, United States.
Benjamin GilbertEnergy Geoscience Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0003-0853-0826
Dominik R HaudenschildDepartment of Orthopedic Surgery, University of California Davis Medical Center, Sacramento, California, 95817, United States.
Gang-Yu LiuBiophysics Graduate Group, University of California, Davis, California 95616, United States.ORCID 0000-0003-3689-0685
University of California, Davis · USInstitute of Biomedical Sciences, Academia Sinica · TWLawrence Berkeley National Laboratory · USUniversity of California Davis Medical Center · US

Funding

Respiratory and Ocular Toxicity of Inhaled NanomaterialsU01ES027288 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PINKERTON, KENT ED, THOMASY, SARA MICHELLE · 2016 to 2020
$2.2M
Multivalent Presentation of Growth Factors Regulates Cellular ResponsesR01AR070239 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAUDENSCHILD, DOMINIK R · 2017 to 2021
$1.6M
NIAMS NIH HHS R01 AR070239NIEHS NIH HHS U01 ES027288
6 · The paper itself

Abstract

The interaction of long nanowires and living cells is directly related to nanowires' nanotoxicity and health impacts. Interactions of silver nanowires (AgNWs) and macrophage cell lines (NR8383) were investigated using laser scanning confocal microscopy and single cell compression (SCC). With high-resolution imaging and mechanics measurement of individual cells, AgNW-induced frustrated phagocytosis was clearly captured in conjunction with structural and property changes of cells. While frustrated phagocytosis is known for long microwires and long carbon nanotubes, this work reports first direct observations of frustrated phagocytosis of AgNWs among living cells in situ. In the case of partial penetration of AgNWs into NR8383 cells, confocal imaging revealed actin participation at the entry sites, whose behavior differs from microwire-induced frustrated phagocytosis. The impacts of frustrated phagocytosis on the cellular membrane and cytoskeleton were also quantified by measuring the mechanical properties using SCC. Taken collectively, this study reveals the structural and property characteristics of nanowire-induced frustrated phagocytosis, which deepens our understanding of nanowire-cell interactions and nanocytotoxicity.

Indexed as

Nanotubes, CarbonNanowiresLungMacrophages, AlveolarPhagocytosisSilverNanotubes, CarbonSilver

Identifiers

PMID33306381
PMCPMC7869824
OpenAlexW3111893917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.