ArticleEuropean heart journal. Cardiovascular Imaging2021
Prevalence and clinical implications of valvular calcification on coronary computed tomography angiography.
Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06660524 (Clinical Study on the Influence of Calcium and Phosphorus Regulation Therapy on Valvular Heart Disease.), which is not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Study on the Influence of Calcium and Phosphorus Regulation Therapy on Valvular Heart Disease.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Anti-Malondialdehyde Low-Density Lipoprotein Antibodies and Valvular Calcification: A Substudy of the SCOT-HEART Trial.Journal of the American Heart Association · 2025Trial
- Beyond the Coronaries: Utility of Extra-Coronary Calcification for Cardiovascular Risk Assessment in Women.Current atherosclerosis reports · 2026Review
- The association between time-weighted cumulative life's essential 8 and aortic valve calcification.Frontiers in cardiovascular medicine · 2026Article
- The triglyceride-glucose index shows a stronger association with complex coronary artery disease than the ACEF score among young and middle-aged adults with aortic valve calcification.Frontiers in cardiovascular medicine · 2026Article
- Circulating CTRP9 and aortic valve calcification jointly predict coronary artery calcification in coronary heart disease patients.Frontiers in nutrition · 2026Article
- Prognostic Value of Pericoronary Adipose Tissue Attenuation After Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis and Obstructive Coronary Artery Disease.Reviews in cardiovascular medicine · 2025Article
- Non-rheumatic calcific aortic valve disease in China: findings from the Global Burden of Disease study 2021.Frontiers in cardiovascular medicine · 2025Article
- Feasibility and Exploration of a Standardized Protocol for Cardiac CT Assessment of Rheumatic Mitral Disease.Reviews in cardiovascular medicine · 2024Review
- Scoring model based on cardiac CT and clinical factors to predict early good mitral valve repair in rheumatic mitral disease.European radiology · 2024Article
- Different prognostic significance of coronary artery and aortic valve calcium in patients with chest pain.European radiology · 2024Article
- Predictive value of valvular calcification for the recurrence of persistent atrial fibrillation after radiofrequency catheter ablation.Clinical cardiology · 2024Article
- Use machine learning models to identify and assess risk factors for coronary artery disease.PloS one · 2024Article
- Noncontrast cardiac computed tomography-derived mitral annular calcification scores in mitral valve disease.Clinical cardiology · 2023Article
- The Influence of Aortic Valve Disease on Coronary Hemodynamics: A Computational Model-Based Study.Bioengineering (Basel, Switzerland) · 2023Article
- Are Non-Invasive Modalities for the Assessment of Atherosclerosis Useful for Heart Failure Predictions?International journal of molecular sciences · 2023Review
- Nomograms Based on the Albumin/Neutrophil-to-Lymphocyte Ratio Score for Predicting Coronary Artery Disease or Subclinical Coronary Artery Disease.Journal of inflammation research · 2023Article
- Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990-2019 Findings from Global Burden of Disease Study 2019.Journal of clinical medicine · 2022Article
- Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy.European heart journal · 2022Article
- Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2021Review
- Nomograms Based on the Advanced Lung Cancer Inflammation Index for the Prediction of Coronary Artery Disease and Calcification.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
aimsValvular heart disease can be identified by calcification on coronary computed tomography angiography (CCTA) and has been associated with adverse clinical outcomes. We assessed aortic and mitral valve calcification in patients presenting with stable chest pain and their association with cardiovascular risk factors, coronary artery disease, and cardiovascular outcomes. METHODS AND
resultsIn 1769 patients (58 ± 9 years, 56% male) undergoing CCTA for stable chest pain, aortic and mitral valve calcification were quantified using Agatston score. Aortic valve calcification was present in 241 (14%) and mitral calcification in 64 (4%). Independent predictors of aortic valve calcification were age, male sex, hypertension, diabetes mellitus, and cerebrovascular disease, whereas the only predictor of mitral valve calcification was age. Patients with aortic and mitral valve calcification had higher coronary artery calcium scores and more obstructive coronary artery disease. The composite endpoint of cardiovascular mortality, non-fatal myocardial infarction, or non-fatal stroke was higher in those with aortic [hazard ratio (HR) 2.87; 95% confidence interval (CI) 1.60-5.17; P < 0.001] or mitral (HR 3.50; 95% CI 1.47-8.07; P = 0.004) valve calcification, but this was not independent of coronary artery calcification or obstructive coronary artery disease.
conclusionAortic and mitral valve calcification occurs in one in six patients with stable chest pain undergoing CCTA and is associated with concomitant coronary atherosclerosis. Whilst valvular calcification is associated with a higher risk of cardiovascular events, this was not independent of the burden of coronary artery disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.