ArticleThe Journal of infectious diseases2021
The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Mosquito-based malaria control through genetic, microbial and immunological innovations.Nature reviews. Microbiology · 2026Review
- Collagenase from Lysinibacillus sphaericus: Production, Optimization and Application in Adipose-Derived Stem Cell Isolation.Applied biochemistry and biotechnology · 2026Article
- High-resolution proteomics unveils salivary gland disruption and saliva-hemolymph protein exchange in Plasmodium-infected mosquitoes.Nature communications · 2025Article
- Antibody responses to gSG6-p1, AgSAP, and SAMSP1 following anopheline salivary exposure.Parasites & vectors · 2025Article
- Avian malaria and the overlooked metabolic pathways underlying mosquitoRoyal Society open science · 2025Article
- Beyond the bite: how mosquito salivary proteins modulate midgut biology and malaria parasite transmission.Current opinion in insect science · 2025Review
- Parasite and vector circadian clocks mediate efficient malaria transmission.Nature microbiology · 2025Article
- Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum-Infected Mosquito Bites.The Journal of infectious diseases · 2025Article
- Advances in the dissection of Anopheles-Plasmodium interactions.PLoS pathogens · 2025Review
- Unraveling the Molecular Mechanisms of Mosquito Salivary Proteins: New Frontiers in Disease Transmission and Control.Biomolecules · 2025Review
- Research progress toward arthropod salivary protein vaccine development for vector-borne infectious diseases.PLoS neglected tropical diseases · 2024Review
- Anopheles gambiae lacking AgTRIO probe inefficiently on a mammalian host.Cell reports · 2024Article
- Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure tomedRxiv : the preprint server for health sciences · 2024Article
- Adiponectin in the mammalian host influences ticks' acquisition of the Lyme disease pathogen Borrelia.PLoS biology · 2023Article
- A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria.NPJ vaccines · 2023Article
- Malaria: influence of Anopheles mosquito saliva on Plasmodium infection.Trends in immunology · 2023Review
- Monoclonal antibodies for malaria prevention.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Review
- A Mosquito AgTRIO Monoclonal Antibody Reduces EarlyInfection and immunity · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Malaria begins when Plasmodium-infected Anopheles mosquitoes take a blood meal on a vertebrate. During the initial probing process, mosquitoes inject saliva and sporozoites into the host skin. Components of mosquito saliva have the potential to influence sporozoite functionality. Sporozoite-associated mosquito saliva protein 1 (SAMSP1; AGAP013726) was among several proteins identified when sporozoites were isolated from saliva, suggesting it may have an effect on Plasmodium. Recombinant SAMSP1 enhanced sporozoite gliding and cell traversal activity in vitro. Moreover, SAMSP1 decreased neutrophil chemotaxis in vivo and in vitro, thereby also exerting an influence on the host environment in which the sporozoites reside. Active or passive immunization of mice with SAMSP1 or SAMSP1 antiserum diminished the initial Plasmodium burden after infection. Passive immunization of mice with SAMSP1 antiserum also added to the protective effect of a circumsporozoite protein monoclonal antibody. SAMSP1 is, therefore, a mosquito saliva protein that can influence sporozoite infectivity in the vertebrate host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.