Evidence map›Paper›PMID 33305655›Full record

ReviewCell cycle (Georgetown, Tex.)2020

Coronavirus disease 2019 (COVID-19), human erythrocytes and the PKC-alpha/-beta inhibitor chelerythrine -possible therapeutic implication.

Mehrdad Ghashghaeinia, Peter Dreischer, Thomas Wieder, Martin Köberle

Open access · hybridAbstract readReview
In one paragraph

Review in Cell cycle (Georgetown, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Molecular Mechanisms and Pathophysiological Significance of Eryptosis.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Review
  8. Observational
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Mehrdad GhashghaeiniaPsoriasis-Center, Department of Dermatology, University Medical Center Schleswig-Holstein , Kiel, Germany.ORCID 0000-0002-1740-594X
Peter DreischerPhysiologisches Institut, Abteilung für Vegetative und Klinische Physiologie, Eberhard Karls University of Tübingen , Tübingen, Germany.
Thomas WiederPhysiologisches Institut, Abteilung für Vegetative und Klinische Physiologie, Eberhard Karls University of Tübingen , Tübingen, Germany.
Martin KöberleDepartment of Dermatology and Allergology, School of Medicine, Technical University of Munich , München, Germany.ORCID 0000-0001-6825-2667
University of Tübingen · DEClinical Research Center Kiel · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. Until now, diverse drugs have been used for the treatment of COVID-19. These drugs are associated with severe side effects, e.g. induction of erythrocyte death, named eryptosis. This massively affects the oxygen (O

Indexed as

COVID-19 Drug TreatmentAntiviral AgentsApoptosisBenzophenanthridinesCOVID-19DNA-Directed RNA PolymerasesErythrocytesHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Protein BiosynthesisProtein Kinase C-alphaProtein Kinase C betaProtein Kinase InhibitorsRespiratory Tract DiseasesRNA VirusesAntiviral AgentsBenzophenanthridineschelerythrineDNA-Directed RNA PolymerasesMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Protein Kinase C-alphaProtein Kinase C betaProtein Kinase Inhibitorschelerythrineerythrocytesmammalian target of rapamycin complex 1 & 2 (mTORC1/-2)protein kinase C-alpha (PKC-α)RNA polymerasesSARS-CoV-2

Identifiers

PMID33305655
PMCPMC7781621
OpenAlexW3112343171

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.