Evidence map›Paper›PMID 33305269›Full record

ArticleNeuro-oncology advances

Improved risk stratification in younger

Kristian Unger, Daniel F Fleischmann, Viktoria Ruf, Jörg Felsberg, Daniel Piehlmaier, Daniel Samaga, Julia Hess, Marian Preetham Suresh, Michel Mittelbronn, Kirsten Lauber and 9 more

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Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 2 countries.

Kristian UngerResearch Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Daniel F FleischmannDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.
Viktoria RufCenter for Neuropathology and Prion Research LMU Munich, Munich, Germany.
Jörg FelsbergInstitute for Neuropathology, University Hospital Düsseldorf (UKD), Heinrich Heine University, Düsseldorf, Germany.
Daniel PiehlmaierResearch Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Daniel SamagaResearch Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Julia HessResearch Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Marian Preetham SureshDepartment of Neurosurgery, University Hospital Düsseldorf (UKD), Heinrich Heine University, Düsseldorf, Germany.
Michel MittelbronnNational Center of Pathology (NCP), Laboratoire National de Santé (LNS), Dudelange, Luxembourg.
Kirsten LauberClinical Cooperation Group "Personalized Radiotherapy in Head and Neck Cancer," Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Wilfried BudachDepartment of Radiotherapy and Radiation Oncology, University Hospital Düsseldorf (UKD), Heinrich Heine University, Düsseldorf, Germany.
Michael SabelDepartment of Neurosurgery, University Hospital Düsseldorf (UKD), Heinrich Heine University, Düsseldorf, Germany.
Claus RödelDepartment of Radiation Oncology, University Hospital, Frankfurt, Germany.
Guido ReifenbergerInstitute for Neuropathology, University Hospital Düsseldorf (UKD), Heinrich Heine University, Düsseldorf, Germany.
Jochen HermsCenter for Neuropathology and Prion Research LMU Munich, Munich, Germany.
Jörg-Christian TonnDepartment of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.
Horst ZitzelsbergerResearch Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Claus BelkaClinical Cooperation Group "Personalized Radiotherapy in Head and Neck Cancer," Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Maximilian NiyaziDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.
Helmholtz Zentrum München · DELudwig-Maximilians-Universität München · DEDüsseldorf University Hospital · DELMU Klinikum · DEDeutschen Konsortium für Translationale Krebsforschung · DEGerman Cancer Research Center · DEHeinrich Heine University Düsseldorf · DELaboratoire National de Santé · LUUniversity Hospital Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe potential benefit of risk stratification using a 4-miRNA signature in combination with

methodsPrimary tumors from 102 patients with comparable treatment from the LMU Munich (

resultsThe 4-miRNA signature defined high-risk (

conclusionThe prognostic 4-miRNA signature in combination with

Indexed as

glioblastomaMGMT promoter methylationmiRNAprognostic signaturerisk stratification

Identifiers

PMID33305269
PMCPMC7712804
OpenAlexW3112232383

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.