Evidence map›Paper›PMID 33305175›Full record

ArticleiScience2020

An

Maëlle Lorvellec, Alessandro Filippo Pellegata, Alice Maestri, Chiara Turchetta, Elena Alvarez Mediavilla, Soichi Shibuya, Brendan Jones, Federico Scottoni, Dany P Perocheau, Andrei Claudiu Cozmescu and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. A Systematic Review on Artificial Liver for Implantation.Journal of functional biomaterials · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Machine Perfusion and Bioengineering Strategies in Transplantation-Beyond the Emerging Concepts.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  8. F1000Research · 2023
    Article
  9. Article
  10. Modelling urea cycle disorders using iPSCs.NPJ Regenerative medicine · 2022
    Review
  11. Recent Advances in Liver Engineering With Decellularized Scaffold.Frontiers in bioengineering and biotechnology · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Maëlle LorvellecMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Alessandro Filippo PellegataDevelopmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Alice MaestriMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Chiara TurchettaDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta," Politecnico di Milano, Milan 20133, Italy.
Elena Alvarez MediavillaGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Soichi ShibuyaDevelopmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Brendan JonesDevelopmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Federico ScottoniDevelopmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Dany P PerocheauGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Andrei Claudiu CozmescuMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Juliette M DelhoveRobinson Research Institute, University of Adelaide, Adelaide, SA, 5006, Australia.
Daniel KyshMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Asllan GjinovciMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
John R CounsellDubowitz Neuromuscular Centre, Molecular Neurosciences Section, Developmental Neurosciences Programme, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Wendy E HeywoodGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Kevin MillsGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Tristan R McKayCentre for Bioscience, Manchester Metropolitan University, Manchester M1 5GD, UK.
Paolo De CoppiDevelopmental Biology and Cancer Research & Teaching Department, Stem Cells & Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Paul GissenMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Great Ormond Street Hospital · GBMRC Laboratory for Molecular Cell Biology · GBManchester Metropolitan University · GBPolitecnico di Milano · ITThe University of Adelaide · AU

Funding

European Research Council 260862Medical Research Council MC_PC_16063Medical Research Council MC_PC_18063Medical Research Council MR/N019075/1Medical Research Council MR/S019111/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/L001780/1Wellcome Trust 210774/Z/18/Z
6 · The paper itself

Abstract

Explosion of gene therapy approaches for treating rare monogenic and common liver disorders created an urgent need for disease models able to replicate human liver cellular environment. Available models lack 3D liver structure or are unable to survive in long-term culture. We aimed to generate and test a 3D culture system that allows long-term maintenance of human liver cell characteristics. The

Indexed as

BioengineeringClinical GeneticsTissue Engineering

Identifiers

PMID33305175
PMCPMC7708813
OpenAlexW3106133570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.