Evidence map›Paper›PMID 33305120›Full record

ArticleKidney international reports2020

Health-Related Quality of Life in People Across the Spectrum of CKD.

Anoushka Krishnan, Armando Teixeira-Pinto, Wai H Lim, Kirsten Howard, Jeremy R Chapman, Antoni Castells, Simon D Roger, Michael J Bourke, Petra Macaskill, Gabrielle Williams and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Effect of online hemodiafiltration on quality of life, fatigue and recovery time: a systematic review and meta-analysis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Workforce Detachment in Persons with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Observational
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 12 institutions in 4 countries.

Anoushka KrishnanSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Armando Teixeira-PintoSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Wai H LimDepartment of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Australia.
Kirsten HowardSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Jeremy R ChapmanCentre for Transplant and Renal Research, Westmead Hospital, Westmead, Australia.
Antoni CastellsGastroenterology Department, Hospital Clinic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.
Simon D RogerDepartment of Renal Medicine, Gosford Hospital, Gosford, Australia.
Michael J BourkeDepartment of Gastroenterology, Westmead Hospital, Westmead, Australia.
Petra MacaskillSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Gabrielle WilliamsSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Charmaine E LokDepartment of Medicine, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada.
Fritz DiekmannDepartment of Nephrology and Kidney Transplantation, Hospital Clínic, Barcelona, Spain.
Nicholas CrossDepartment of Nephrology and Kidney Transplantation, Christchurch Hospital and Otago University, Christchurch, New Zealand.
Shaundeep SenSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Richard D M AllenDepartment of Renal Medicine, Royal Prince Alfred Hospital, and Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Steven J ChadbanDepartment of Renal Medicine, Royal Prince Alfred Hospital, and Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Carol A PollockDepartment of Medicine, Northern Clinical School, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Robin TurnerSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Allison TongSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Jean Y H YangSchool of Mathematics and Statistics, The University of Sydney, Sydney, Australia.
Narelle WilliamsSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Eric AuSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Anh KieuSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Laura JamesSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Anna FrancisSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Germaine WongSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Adelaide, Australia.
The University of Sydney · AUWestmead Hospital · AURoyal Prince Alfred Hospital · AUChristchurch Hospital · NZConcord Repatriation General Hospital · AUFlinders University · AUGosford Hospital · AUHospital Clínic de Barcelona · ESRoyal North Shore Hospital · AUSir Charles Gairdner Hospital · AUToronto General Hospital · CAUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeople with chronic kidney disease (CKD) experience reduced quality of life (QoL) because of the high symptom and treatment burden. Limited data exist on the factors associated with overall and domain-specific QoL across all CKD stages.

methodsUsing data from a prospective, multinational study (Australia, New Zealand, Canada, and Spain) in 1696 participants with CKD, we measured overall and domain-specific QoL (pain, self-care, activity, mobility, anxiety/depression) using the EuroQoL, 5 dimension, 3 level. Multivariable linear regression and logistic modeling were used to determine factors associated with overall and domain-specific QoL.

resultsQoL for patients with CKD stages 3 to 5 (n = 787; mean, 0.81; SD, 0.20) was higher than in patients on dialysis (n = 415; mean, 0.76; SD, 0.24) but lower than in kidney transplant recipients (n = 494; mean, 0.84; SD, 0.21). Factors associated with reduced overall QoL (β [95% confidence intervals]) included being on dialysis (compared with CKD stages 3-5: -0.06 [-0.08 to -0.03]), female sex (-0.03 [-0.05 to -0.006]), lower educational attainment (- 0.04 [-0.06 to -0.02), lacking a partner (-0.04 [-0.06 to -0.02]), having diabetes (-0.05 [-0.07 to -0.02]), history of stroke (-0.09 [-0.13 to -0.05]), cardiovascular disease (-0.06 [-0.08 to -0.03]), and cancer (-0.03 [-0.06 to -0.009]). Pain (43%) and anxiety/depression (30%) were the most commonly affected domains, with dialysis patients reporting decrements in all 5 domains. Predictors for domain-specific QoL included being on dialysis, presence of comorbidities, lower education, female sex, and lack of a partner.

conclusionsBeing on dialysis, women with CKD, those with multiple comorbidities, lack of a partner, and lower educational attainment were associated with lower QoL across all stages of CKD.

Indexed as

chronic kidney diseasedomain-specific QoLEuroQoL-5D3Lquality of life

Identifiers

PMID33305120
PMCPMC7710842
OpenAlexW3090770909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.