Evidence map›Paper›PMID 33305112›Full record

ArticleKidney international reports2020

Conversion From Belatacept to Another Immunosuppressive Regimen in Maintenance Kidney-Transplantation Patients.

Anna Gouin, Rebecca Sberro-Soussan, Cécile Courivaud, Dominique Bertrand, Arnaud Del Bello, Amandine Darres, Didier Ducloux, Christophe Legendre, Nassim Kamar

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Back to the Future With Co-Stimulation Blockade.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Anna GouinDepartment of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
Rebecca Sberro-SoussanService de néphrologie-Transplantation, Hôpital Necker, AP-HP, Paris et Université Paris Descartes, Paris.
Cécile CourivaudService de néphrologie, dialyse et transplantation rénale, FHU INCREASE, CHU de Besançon, Besançon, France.
Dominique BertrandService de néphrologie, dialyse et transplantation rénale, CHU de Rouen, Rouen, France.
Arnaud Del BelloDepartment of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
Amandine DarresDepartment of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
Didier DuclouxService de néphrologie, dialyse et transplantation rénale, FHU INCREASE, CHU de Besançon, Besançon, France.
Christophe LegendreService de néphrologie-Transplantation, Hôpital Necker, AP-HP, Paris et Université Paris Descartes, Paris.
Nassim KamarDepartment of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
Centre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Toulouse · FRDélégation Paris 5 · FRCentre Hospitalier Universitaire de Rouen · FRInserm · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDuring the coronavirus disease 2019 (Covid-19) pandemic, several physicians have questioned pursuing belatacept in kidney-transplant patients in order to reduce the risk of nosocomial transmission during the monthly infusion. The effect of the conversion from belatacept to another immunosuppressive regimen is underreported. The aim of the present retrospective study was to assess the effect on kidney function and the clinical outcome of the conversion from belatacept to another regimen.

methodsWe have identified 44 maintenance kidney transplantation patients from five French kidney transplantation centers who were converted from belatacept to another regimen either because of a complication (n = 28) or another reason (patients' request or belatacept shortage, n = 13). The follow-up after the conversion from belatacept was 27.5 ± 25.3 months.

resultsOverall, mean estimated glomerular filtration rate (eGFR) decreased from 44.2 ± 16 ml/min per 1.73 m

conclusionsThus, transplantation physicians should avoid stopping belatacept when not clinically required.

Indexed as

belataceptcalcineurin inhibitorconversiondonor-specific antibodykidney functionsafety

Identifiers

PMID33305112
PMCPMC7710888
OpenAlexW3092093341

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.