Evidence map›Paper›PMID 33305108›Full record

ArticleKidney international reports2020

Water-Soluble Vitamin Levels and Supplementation in Chronic Online Hemodiafiltration Patients.

Nora Schwotzer, Michiko Kanemitsu, Sebastien Kissling, Roger Darioli, Mohammed Benghezal, Serge Rezzi, Michel Burnier, Menno Pruijm

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. A Simultaneous Determination of the BInternational journal of molecular sciences · 2025
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  12. Assessment of Dietary Folate Intake and Pill Burden among Saudi Patients on Maintenance Hemodialysis.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nora SchwotzerService of Nephrology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Michiko KanemitsuService of Nephrology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Sebastien KisslingService of Nephrology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Roger DarioliSwiss Vitamin Institute, Epalinges, Switzerland.
Mohammed BenghezalSwiss Vitamin Institute, Epalinges, Switzerland.
Serge RezziSwiss Vitamin Institute, Epalinges, Switzerland.
Michel BurnierService of Nephrology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Menno PruijmService of Nephrology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSupplementation of water-soluble vitamins is a common practice in hemodialysis patients, but dosages are largely based on conventional hemodialysis techniques. The aim of this study was to assess the status of water-soluble vitamins in patients on hemodiafiltration (HDF), and attempt to determine optimal dose of vitamin supplements.

methodsThis monocentric study included 40 patients on thrice-weekly chronic HDF. At baseline, all patients received 2 tablets of Dialvit containing B and C vitamins after each dialysis session. Predialysis samples of B and C vitamins were measured in both blood (

resultsAt baseline, B-vitamin levels were high with, respectively, 0.4%, 10.0%, and 89.6% of patients in the low, normal, and high reference range. For vitamin C, most patients were in the normal range (5.0%, 82.5%, and 12.5% in low, normal, and high reference range). Three months after dose reduction, B vitamin levels decreased but stayed mostly at or above the normal range (1.4%, 25.7%, 72.9% in low, normal, and high reference range). Three patients (12.5%) developed vitamin C deficiency on low-dose substititon.

conclusionThis study shows that the levels of most vitamins are above the normal range in patients on HDF receiving a classic dose of vitamin supplements, vitamin C excepted. Our study suggests that the classic dose of postdialysis vitamin B supplements may be reduced.

Indexed as

clearancehemodiafiltrationhemodialysisvitamin Bvitamin C

Identifiers

PMID33305108
PMCPMC7710883
OpenAlexW3085994570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.