Evidence map›Paper›PMID 33304997›Full record

ArticleACS biomaterials science & engineering2019

Drug-Mimicking Nanofibrous Peptide Hydrogel for Inhibition of Inducible Nitric Oxide Synthase.

David G Leach, Jared M Newton, Marcus A Florez, Tania L Lopez-Silva, Adrianna A Jones, Simon Young, Andrew G Sikora, Jeffrey D Hartgerink

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. 3D Printing of Self-Assembling Nanofibrous Multidomain Peptide Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2023
    Article
  5. Self-assembling peptides as immunomodulatory biomaterials.Frontiers in bioengineering and biotechnology · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Biomaterial-Facilitated Immunotherapy for Established Oral Cancers.ACS biomaterials science & engineering · 2021
    Article
  12. Article
  13. Current Progress in Cross-Linked Peptide Self-Assemblies.International journal of molecular sciences · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

David G LeachDepartment of Chemistry and Department of Bioengineering, Rice University, Houston, Texas 77005, United States.
Jared M NewtonDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas 77030, United States.
Marcus A FlorezDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas 77030, United States.
Tania L Lopez-SilvaDepartment of Chemistry and Department of Bioengineering, Rice University, Houston, Texas 77005, United States.
Adrianna A JonesDepartment of Chemistry and Department of Bioengineering, Rice University, Houston, Texas 77005, United States.
Simon YoungDepartment of Oral & Maxillofacial Surgery, University of Texas Health Science Center, Houston, Texas 77054, United States.
Andrew G SikoraDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas 77030, United States.
Jeffrey D HartgerinkDepartment of Chemistry and Department of Bioengineering, Rice University, Houston, Texas 77005, United States.ORCID 0000-0002-3186-5395
Rice University · USBaylor College of Medicine · USThe University of Texas Health Science Center at Houston · US

Funding

Targeting the immunosuppressive tumor microenvironment to enhance efficacy of radiotherapy and immuno-radiotherapy for oral cancerU01DE028233 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANNAPRAGADA, ANANTH V, SIKORA, ANDREW · 2018 to 2022
$3.9M
Self-assembling Peptide Nanofiber Hydrogels for Nerve RegenerationR01DE021798 · NIDCR · RICE UNIVERSITY · PI HARTGERINK, JEFFREY DALE · 2012 to 2021
$3.7M
Training Program in Translational Biology and Molecular MedicineT32GM088129 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROONEY, CLIONA M., VAN DEN VEYVER, IGNATIA B · 2010 to 2019
$3.0M
Autophagy-promoting NLRX1-TUFM complex and cancer cell resistance to cetuximabR00DE024173 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEI, YU LEO · 2016 to 2018
$863k
STINGel Immunotherapy for Treatment-Resistant Head and Neck CancerR21DE027794 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YOUNG, SIMON · 2018 to 2019
$440k
Autophagy-promoting NLRX1-TUFM complex and cancer cell resistance to cetuximabK99DE024173 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEI, YU LEO · 2014 to 2015
$254k
Immunomodulatory Nanoparticles in Combination with Immune Checkpoint Inhibitors for the Systemic Treatment of Immunosuppressive HPV Associated Oropharyngeal CancerF31DE026682 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI NEWTON, JARED MICHAEL · 2016 to 2019
$118k
NIDCR NIH HHS F31 DE026682NIDCR NIH HHS K99 DE024173NIDCR NIH HHS R00 DE024173NIDCR NIH HHS R01 DE021798NIDCR NIH HHS R21 DE027794NIDCR NIH HHS U01 DE028233NIGMS NIH HHS T32 GM088129
6 · The paper itself

Abstract

In this work, we develop a drug-mimicking nanofibrous peptide hydrogel that shows long-term bioactivity comparable to a small-molecule inhibitor of inducible nitric oxide synthase (iNOS). The iNOS inhibitor,

Indexed as

hydrogeliNOS inhibitionpeptideself-assembly

Identifiers

PMID33304997
PMCPMC7725238
OpenAlexW2985859698

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.