Evidence map›Paper›PMID 33304951›Full record

ArticleData in brief2020

Dataset of the construction and characterization of stable biological nanoparticles.

Romina A Gisonno, M Alejandra Tricerri, Marina C Gonzalez, Horacio A Garda, Nahuel A Ramella, Ivo Díaz Ludovico

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Romina A GisonnoInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Argentina.
M Alejandra TricerriInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Argentina.
Marina C GonzalezInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Argentina.
Horacio A GardaInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Argentina.
Nahuel A RamellaInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Argentina.
Ivo Díaz LudovicoInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Argentina.
Biochemistry Research Institute of La Plata · ARUniversidad Nacional de La Plata · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article shows the dataset of clearance assays and the reconstitution of stable biological nano-complexes using both detergent-assisted and spontaneous solubilization of phospholipids by the recombinant purified apolipoprotein A-I (apoA-I). Protein was intra-chain crosslinked in order to introduce steric constrains. Then, native and crosslinked protein function was evaluated by a data collection of dimiristoyl phosphatidyl choline (DMPC) micellization curves. Additionally, resulting particles from spontaneous or detergent-assisted lipid solubilization were characterized by transmission electron microscopy (TEM), size exclusion chromatography (SEC), and native polyacrylamide gel electrophoresis (PAGE). Here we set up an experimental design that may help study protein structure based on its function, since interaction with biological membranes and lipids is an intrinsic activity attributed to many proteins in circulation. In addition, by

Indexed as

Apolipoprotein A-IBS3 crosslinkerGradient gel electrophoresisLipid-bindingNanoparticles

Identifiers

PMID33304951
PMCPMC7708788
OpenAlexW3103126129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.