ArticleFrontiers in cell and developmental biology2020
Construction and Validation of a Cell Cycle-Related Robust Prognostic Signature in Colon Cancer.
Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Kinase-based molecular subtyping and a prognostic risk model in colorectal cancer with functional validation of PLK4.Translational cancer research · 2026Article
- α-hederin inhibits cervical cancer progression by inducing DNA damage-dependent cell cycle blockade and apoptosis.BMC cancer · 2025Article
- Exploring the mystery of colon cancer from the perspective of molecular subtypes and treatment.Scientific reports · 2024Article
- Article
- Differential gene expression of immunity and inflammation genes in colorectal cancer using targeted RNA sequencing.Frontiers in oncology · 2023Article
- Construction and validation of a prognostic model based on ten signature cell cycle-related genes for early-stage lung squamous cell carcinoma.Cancer biomarkers : section A of Disease markers · 2023Article
- A novel epithelial-mesenchymal transition (EMT)-related gene signature of predictive value for the survival outcomes in lung adenocarcinoma.Frontiers in oncology · 2022Article
- Molecular Classification Based on Prognostic and Cell Cycle-Associated Genes in Patients With Colon Cancer.Frontiers in oncology · 2021Article
- A four-gene prognostic signature for predicting the overall survival of patients with lung adenocarcinoma.PeerJ · 2021Article
- Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub-Proteasome System and Cell Cycle in Colorectal Cancer.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colon cancer is one of the most common cancers, great progress was taken place in the treatment of colon cancer, however, the prognostic assessment system remains lagging. Cell cycle plays a vital role in the whole procedure of cancers. In this study, we firstly identified cell cycle-related genes specific in colon cancer. Functional enrichment analysis proved our analysis reliable. Furthermore, we constructed a robust signature based on the cell cycle-related genes. The AUC of the signature to predict the overall survival was 0.808, 0.807, and 0.831 of AUC at 1, 3, and 5 years, respectively. Internal and external validation proved the signature efficient. The 9 genes involved in the signature also showed a great job in molecular subgrouping which indicated the significant value of the 9 genes for further experimental research. In conclusion, the present research provided a novel robust signature predicting the prognosis of colon cancer.
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