Evidence map›Paper›PMID 33304900›Full record

ArticleFrontiers in cell and developmental biology2020

Neural Tube Defects and

Yun Huang, Shanshan Lin, Chengrong Wang, Xin Pi, Lei Jin, Zhiwen Li, Linlin Wang, Aiguo Ren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yun HuangNational Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, Institute of Reproductive and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China.
Shanshan LinDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Chengrong WangBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Xin PiDepartment of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, China.
Lei JinNational Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, Institute of Reproductive and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China.
Zhiwen LiNational Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, Institute of Reproductive and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China.
Linlin WangNational Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, Institute of Reproductive and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China.
Aiguo RenNational Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, Institute of Reproductive and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China.
National Health and Family Planning Commission · CNPeking University · CNBeijing Obstetrics and Gynecology Hospital · CNGuangzhou Medical University · CNXinHua Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpigenetic dysregulation is one of the postulated underlying mechanisms of neural tube defects (NTDs). Polycyclic aromatic hydrocarbons (PAHs), a group of environmental pollutants that are reported as a risk factor of NTDs, may cause decreased genome-wide DNA methylation. With DNA extracted from neural tissues, this study identified gene(s) whose hypomethylation was related to elevated risk for NTDs and examined whether its hypomethylation is related to PAH exposure.

resultsUsing data profiled by Infinium HumanMethylation450 BeadChip array from 10 NTD cases and eight controls,

conclusionHypomethylation of the

Indexed as

DNA methylationneural tube defectsoxidative stresspolycyclic aromatic hydrocarbonsZic4

Identifiers

PMID33304900
PMCPMC7701213
OpenAlexW3101936276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.